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MetabolomicsBrown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...
2022-03-03 | MTBLS2436 | MetaboLights
TranscriptomicsEffects of dexamethasone on human skeletal muscle and adipose tissue
Context: Glucocorticoids are frequently prescribed drugs with important side-effects such as glucose intolerance and tissue remodelling. Objective: The goal was to explore the molecular basis of the crosstalk between adipose tissue and skeletal muscle during short term glucocorticoid treatment. Des...
ORGANISM(S): Homo sapiens 
2011-11-28 | E-GEOD-17992 | biostudies-arrayexpress
ProteomicsLGR signaling mediates muscle-adipose tissue crosstalk and protects against diet-induced insulin resistance
Obesity impairs tissue insulin sensitivity and signaling, promoting type-2 diabetes. Although improving insulin signaling is key to reversing diabetes, the multi-organ mechanisms regulating this process are poorly defined. We screened the secretome and receptome in Drosophila to identify the hormona...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-27 | PXD053061 | Pride
Phosphoproteomics Muscle-adipose tissue crosstalk Lgr Insulin resistance T2d 
UnknownSignal regulatory protein alpha initiates cachexia through muscle to adipose tissue crosstalk.
Not available
S-EPMC6903446 | biostudies-literature
UnknownMyricanol modulates skeletal muscle-adipose tissue crosstalk to alleviate high-fat diet-induced obesity and insulin resistance.
Not available
S-EPMC6811775 | biostudies-literature
UnknownIrisin Attenuates Muscle Impairment during Bed Rest through Muscle-Adipose Tissue Crosstalk.
Not available
S-EPMC9311907 | biostudies-literature
UnknownLGR signaling mediates muscle-adipose tissue crosstalk and protects against diet-induced insulin resistance.
Not available
S-EPMC11271308 | biostudies-literature
UnknownAdipose-Muscle Crosstalk in COPD Cachexia: Early Adipose Atrophy Drives Subsequent Muscle Wasting.
Not available
S-EPMC12688405 | biostudies-literature
UnknownPrediction of the Secretome and the Surfaceome: A Strategy to Decipher the Crosstalk between Adipose Tissue and Muscle during Fetal Growth.
Not available
S-EPMC7353064 | biostudies-literature
UnknownPentamethylquercetin Regulates Lipid Metabolism by Modulating Skeletal Muscle-Adipose Tissue Crosstalk in Obese Mice.
Not available
S-EPMC9227162 | biostudies-literature
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