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ProteomicsProteome of the cortex of old Pink1-SNCA A53T double mutant Parkinson mice
Parkinson's Disease (PD) is primarily caused by aggregates of alpha synuclein (SNCA) in dopaminergic neurons of the substantia nigra, but PD is a systemic disease and may lead to PD-associated dementia complex. PD-associated encephalopathy is a late manifestation in PD patients at risk for example o...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-21 | PXD039172 | Pride
Lc-ms/ms Mutant alpha synuclein (snca-a53t) Parkinson's disease Pten-induced kinase 1 Pd-associated encephalopathy 
TranscriptomicsPotentiation of neurotoxicity in double mutant mice with Pink1 ablation and A53T-SNCA overexpression
As the second most frequent neurodegenerative disorder of old age, ParkinsonM-bM-^@M-^Ys disease (PD) can result from autosomal dominant causes like increased alpha-synuclein (SNCA) dosage, or from autosomal recessive causes like PINK1 loss-of-function. Interactions between these triggers and their ...
ORGANISM(S): Mus musculus 
2014-11-04 | E-GEOD-60414 | biostudies-arrayexpress
UnknownPotentiation of neurotoxicity in double-mutant mice with Pink1 ablation and A53T-SNCA overexpression.
Not available
S-EPMC4986551 | biostudies-literature
UnknownMutant α-Synuclein Overexpression Induces Stressless Pacemaking in Vagal Motoneurons at Risk in Parkinson's Disease.
Not available
S-EPMC6705667 | biostudies-literature
UnknownImpaired Photic Entrainment of Spontaneous Locomotor Activity in Mice Overexpressing Human Mutant α-Synuclein.
Not available
S-EPMC6032049 | biostudies-literature
TranscriptomicsPotentiation of neurotoxicity in double mutant mice with Pink1 ablation and A53T-SNCA overexpression
As the second most frequent neurodegenerative disorder of old age, Parkinson’s disease (PD) can result from autosomal dominant causes like increased alpha-synuclein (SNCA) dosage, or from autosomal recessive causes like PINK1 loss-of-function. Interactions between these triggers and their potential ...
ORGANISM(S): Mus musculus 
2014-11-04 | GSE60414 | GEO
UnknownMutant α-synuclein causes death of human cortical neurons via ERK1/2 and JNK activation.
Not available
S-EPMC10916047 | biostudies-literature
TranscriptomicsParkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration
Parkinson's disease (PD) is an adult-onset movement disorder of largely unknown etiology. We have previously shown that loss-of-function mutations of the mitochondrial protein kinase PINK1 (PTEN induced putative kinase 1) cause the recessive PARK6 variant of PD. Now we generated a PINK1 deficient mo...
ORGANISM(S): Mus musculus 
2014-11-04 | E-GEOD-60413 | biostudies-arrayexpress
UnknownIntracerebral Administration of a Ligand-ASO Conjugate Selectively Reduces α-Synuclein Accumulation in Monoamine Neurons of Double Mutant Human A30P*A53T*α-Synuclein Transgenic Mice.
Not available
S-EPMC8001805 | biostudies-literature
UnknownDevelopment and Application of High-Throughput Single Cell Lipid Profiling: A Study of SNCA-A53T Human Dopamine Neurons.
Not available
S-EPMC7644967 | biostudies-literature
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