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TranscriptomicsTargeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia
Homeobox (HOX) proteins and the receptor tyrosine kinase FLT3 are frequently highly expressed and mutated in acute myeloid leukemia (AML). Aberrant HOX expression is found in nearly all AMLs that harbor a mutation in the Nucleophosmin (NPM1) gene, and FLT3 is concomitantly mutated in approximately 6...
ORGANISM(S): Homo sapiens 
2016-08-22 | E-GEOD-85107 | biostudies-arrayexpress
TranscriptomicsNPM1 mutation-modulated microRNA−mRNA regulation in acute myeloid leukemia [mRNA]
Mutation in the nucleophosmin (NPM1) gene is frequent in acute myeloid leukemia (AML). This mutation has remarkable prognostic significance and correlates with distinct biological features. Our data from the sample-paired microRNA (miRNA) and mRNA microarrays of de novo AML patients strongly indicat...
ORGANISM(S): Homo sapiens 
2017-05-03 | E-GEOD-68466 | biostudies-arrayexpress
TranscriptomicsNPM1 mutation-modulated microRNA−mRNA regulation in acute myeloid leukemia [miRNA]
Mutation in the nucleophosmin (NPM1) gene is frequent in acute myeloid leukemia (AML). This mutation has remarkable prognostic significance and correlates with distinct biological features. Our data from the sample-paired microRNA (miRNA) and mRNA microarrays of de novo AML patients strongly indicat...
ORGANISM(S): Homo sapiens 
2017-05-03 | E-GEOD-68467 | biostudies-arrayexpress
ProteomicsRibosome biogenesis factors are post-transcriptionally depleted in NPM1-mutant acute myeloid leukemia and can be targeted therapeutically
Mutations in the NPM1 gene are found in more than 30% of acute myeloid leukemia (AML) cases. The mutations disrupt a nucleolar localization signal (NoLS) and create a novel nuclear export signal (NES), leading to cytoplasmic displacement of the protein (NPM1c). NPM1c mutations prime hematopoietic pr...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-27 | PXD053249 | Pride
Npm1 Proteomics Tmt Ribososme biogenesis 
ProteomicsDetermination of protein expression changes due to treatment with chromatin remodeling inhibitor FHD-286 in patient-derived mutant NPM1 and FLT-ITD-expressing AML cells
We treated patient-derived mutant NPM1-and FLT3-ITD expressing AML cells with a chromatin remodeling inhibitor, FHD-286, at a dose of 100 nM, for 48 hours to determine FHD-286-mediated changes to the AML proteome.
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD047967 | Pride
Chromatin remodelers Mutant npm1 Aml Fhd-286 
TranscriptomicsDetection of mutant NPM1 mRNA in acute myeloid leukemia (AML) using custom gene expression arrays [Training cohort]
Abstract Mutations in the gene encoding nucleophosmin (NPM1) carry prognostic value for patients with acute myeloid leukemia (AML). Various techniques are currently being used to detect these mutations in routine molecular diagnostics. Incorporation of accurate NPM1 mutation detection on a gene expr...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-42194 | biostudies-arrayexpress
TranscriptomicsNPM1 mutation-modulated microRNA-mRNA regulation in acute myeloid leukemia
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2017-05-03 | E-GEOD-68469 | biostudies-arrayexpress
GenomicsMutant NPM1 binds chromatin and directly regulates oncogenic transcription in acute myeloid leukemia [ChIP-seq]
Mutant NPM1 binds chromatin and directly regulates oncogenic transcription in acute myeloid leukemia [ChIP-seq]
PRJNA805173 | ENA
GenomicsMutant NPM1 marginally impacts ribosome footprint in acute myeloid leukemia cells
Mutant NPM1 marginally impacts ribosome footprint in acute myeloid leukemia cells
PRJNA1055925 | ENA
TranscriptomicsDetection of mutant NPM1 mRNA in acute myeloid leukemia (AML) using custom gene expression arrays [Validation cohort]
Abstract Mutations in the gene encoding nucleophosmin (NPM1) carry prognostic value for patients with acute myeloid leukemia (AML). Various techniques are currently being used to detect these mutations in routine molecular diagnostics. Incorporation of accurate NPM1 mutation detection on a gene expr...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-42200 | biostudies-arrayexpress
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