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MetabolomicsThe Inhibition of B7H3 by 2-HG Accumulation Is Associated With Downregulation of VEGFA in IDH Mutated Gliomas
B7H3 (also known as CD276) is a co-stimulator checkpoint protein of the cell surface B7 superfamily. Recently, the function beyond immune regulation of B7H3 has been widely studied. However, the expression preference and the regulation mechanism underlying B7H3 in different subtypes of gliomas is ra...
2021-05-26 | MTBLS2692 | MetaboLights
TranscriptomicsAML with mutated NPM1 carrying a normal or aberrant karyotype show overlapping features
AML with mutated NPM1 usually carries normal karyotype (NK) but it may harbor chromosomal aberrations whose significance remains unclear. We addressed this question in 631 AML patients with mutated/cytoplasmic NPM1. An abnormal karyotype (AK) was present in 93/631 cases (14.7%), the most frequent ab...
ORGANISM(S): Homo sapiens 
2009-06-01 | E-GEOD-16015 | biostudies-arrayexpress
TranscriptomicsExpression profiling in WT vs CDKL5 mutated IPSCs
Mutations in the human CDKL5 gene have been associated with early onset seizure variant of Rett Syndrome. In order to investigate the potential involvement of CDKL5 in the regulation of gene expression, we compared expression profiles in WT vs CDKL5-mutated IPS clones from two patients (one male and...
ORGANISM(S): Homo sapiens 
2014-07-02 | E-MTAB-2223 | biostudies-arrayexpress
TranscriptomicsEffect of TERT and ATM on Gene Expression Profiles in Human Fibroblasts
Gene expression profiling was performed by use of serial analysis of gene expression (SAGE) on BJ normal human skin fibroblasts, A-T cells, and BJ and A-T cells transduced with hTERT cDNA and expressing telomerase activity. Keywords = telomere Keywords = telomerase Keywords = TERT Keywords = ataxia ...
ORGANISM(S): Homo sapiens 
2004-01-16 | E-GEOD-953 | biostudies-arrayexpress
TranscriptomicsEfficacy of retinoids in IKZF1-mutated BCR-ABL1 acute lymphoblastic leukemia
Alterations of IKZF1, encoding the lymphoid transcription factor IKAROS, are a hallmark of high risk acute lymphoblastic leukemia (ALL), however the role of IKZF1 alterations in ALL pathogenesis is poorly understood. Here we show that in mouse models of BCR-ABL1 leukemia, Ikzf1 and Arf alterations s...
ORGANISM(S): Mus musculus 
2015-09-04 | E-GEOD-68391 | biostudies-arrayexpress
GenomicsMutated b-catenin Gene Signature to Identify CTNNB1-mutated and Immune Checkpoint Resistant Hepatocellular Cancers
Mutated b-catenin Gene Signature to Identify CTNNB1-mutated and Immune Checkpoint Resistant Hepatocellular Cancers
PRJNA1086482 | ENA
TranscriptomicsMultilineage dysplasia and AML with mutated nucleophosmin
Multilineage dysplasia (MLD) has no impact on biological, clinico-pathological and prognostic features of AML with mutated nucleophosmin (NPM1) NPM1-mutated AML is a provisional entity in the WHO-2008 classification of myeloid neoplasms. The significance of concomitant multilineage dysplasia (MLD) i...
ORGANISM(S): Homo sapiens 
2010-07-30 | E-GEOD-18018 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of gene expression in ATM-deficient MEFs
The expression of interferon-related genes was more enhanced in irradiated ATM-deficient mouse embryonic fibroblasts (MEFs) than in irradiated ATM wild-type MEFs. Nonirradiated-ATM-WT vs Irradiated-ATM-WT vs Nonirradaited-ATM-KO vs IrradiatedATM-KO
ORGANISM(S): Mus musculus 
2012-06-19 | E-GEOD-23116 | biostudies-arrayexpress
TranscriptomicsThe RALA pathway can maintain the proliferation of KRAS- and BRAF-mutated cancer cells
By silencing of RALA, a downstream member of the RAS signal transduction pathway, we aimed to determine whether genes downstream of a mutated KRAS (codon 12 or 13) or a mutated BRAF can have significant functions in colorectal cancer carcinogenesis. RALA was silenced in three colorectal cancer cell ...
ORGANISM(S): Homo sapiens 
2015-06-20 | E-GEOD-39857 | biostudies-arrayexpress
TranscriptomicsCPG stimulation for Gene Expression of mutated B-CLL
The aim is to identify the differential gene expression profile of mutated B-CLL stimulated with CPG Two-condition experiment, CPG-stimulated B-CLL mutated vs. Unstimulated B-CLL mutated . Biological replicates: 8 unstimulated replicates, 8 CPG-stimulated replicates. Reference design;
ORGANISM(S): Homo sapiens 
2011-08-17 | E-GEOD-31360 | biostudies-arrayexpress
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