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Genomics
Suppression of Transcription-Replication Conflicts by Sequence-Coordinated Actions of TRDMT1 and MutL-alpha
PRJNA1478282 | ENA
TranscriptomicsTranscription profiling of Xenopus laevis early gastrulation embryos injected with alpha-amanitin against RNA polymerase II activity
Xenopus laevis embryos were injected with alpha-amanitin to inhibit RNA polymerase II activity. Embryos were allowed to develop up to stage 10.5 (early gastrula, control and alpha-amanitin injected embryos) and subsequently collected for RNA isolation. The transcriptome profiles of alpha-amanitin in...
ORGANISM(S): Xenopus laevis 
2016-03-07 | E-MTAB-3614 | biostudies-arrayexpress
TranscriptomicsChromosome fragility at the expanded GAA/TTC tracks depends on repeat orientation and requires mismatch repair system.
Expansion of triplex-forming GAA/TTC repeats in the first intron of FRDA gene is known to cause Friedreich’s ataxia. Besides FRDA, there are a number of other highly polymorphic GAA/TTC loci in the human genome where the size variations so far were considered to be a neutral event. Using yeast as ...
ORGANISM(S): Saccharomyces cerevisiae 
2008-05-14 | E-GEOD-11425 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of IFN-response
Type I interferon (IFN-α/β) is the first line of defense against viral infection. Mouse models have been pivotal to our understanding of IFN-α/β in immunity, although validation of these findings in humans has not been possible. We investigated a previously healthy child with fatal susceptibility to...
ORGANISM(S): Homo sapiens 
2015-06-12 | E-GEOD-67737 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of the effects of ASP/MSH in melan-a melanocytes
We determined the gene expression profiles of murine melan-a melanocytes treated with ASP or alpha-MSH over a 4 days time course using genome-wide oligonucleotide microarrays. As expected, the gene expression patterns emphasized the opposing effects of the 2 ligands, and there were significant reduc...
ORGANISM(S): Mus musculus 
2009-02-02 | E-GEOD-14089 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of peripheral blood or primary finroblast cultures from choroideremia patients to determine if loss-of-function mutations in REP-1 affect intracellular vesicle transport in fibroblasts and monocytes of CHM patients
Choroideremia (CHM) is a progressive X-linked retinopathy caused by mutations in the CHM gene, which encodes Rab escort protein-1 (REP-1), an escort protein involved in the prenylation of Rabs. Under-prenylation of certain Rabs, as a result of loss of function mutations in REP-1, could affect vesicu...
ORGANISM(S): Homo sapiens 
2010-02-21 | E-GEOD-17549 | biostudies-arrayexpress
UnknownHigh rate of CAD gene amplification in human cells deficient in MLH1 or MSH6.
Not available
S-EPMC61122 | biostudies-literature
GenomicsChromosome fragility at the expanded GAA/TTC tracks depends on repeat orientation and requires mismatch repair system.
Expansion of triplex-forming GAA/TTC repeats in the first intron of FRDA gene is known to cause Friedreich’s ataxia. Besides FRDA, there are a number of other highly polymorphic GAA/TTC loci in the human genome where the size variations so far were considered to be a neutral event. Using yeast as a ...
ORGANISM(S): Saccharomyces cerevisiae 
2008-05-14 | GSE11425 | GEO
UnknownRapid induction of chromatin-associated DNA mismatch repair proteins after MNNG treatment.
Not available
S-EPMC2483959 | biostudies-literature
TranscriptomicsTranscription profiling of E. coli dam and mutS mutants exposed to cisplatin
We used Affymetrix microarrays to determine the cisplatin-induced gene expression changes in E. coli deficient in dam and mismatch repair (dam, dam mutS, and mutS mutant strains). E. coli deficient in dam are hypersensitive to cisplatin. However introducing an additional mutation in mismatch repai...
ORGANISM(S): Escherichia coli 
2007-07-19 | E-GEOD-2999 | biostudies-arrayexpress
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