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Genome wide CRISPR screen for Sorafenib resistance in MOLM13 and MV411 cells using Y. Kosuke library

PRJNA575535 | ENA

Homo sapiens

MV411 cell Transcriptome

PRJNA1468412 | ENA

Genome wide CRISPR screen for Sorafenib resistance in MOLM13 and MV411 cells using Y. Kosuke library

MOLM13 or MV411 cells were generated to express Cas9, infected with CRISPR library (Tzelepis et al 2016) , selected for puromycin resistance and exposed to Sorafenib (50nM), Crenolanib (20nM) or vehicle, DMSO. Cells were collected at time 0 (post puromycin selection), day 7 and 14 for Sorafenib as w...

ORGANISM(S): Homo sapiens

2021-05-19 | GSE138343 | GEO

Design, synthesis and activity evaluation of arctigenin derivatives with HDAC inhibition activity.

Not available

S-EPMC10951978 | biostudies-literature

Inhibition of bromodomain and extra-terminal (BET) recruitment to chromatin as an effective treatment for mixed lineage leukaemia (MLL)-fusion leukaemia

Gene expression changes in MLL leukaemia following I-BET151 treatment. Note: Additional archives available (E-MTAB-774.additional.1.zip and E-MTAB-774.additional.2.zip) containing individual raw files. Select 'Browse all available files' to view.

ORGANISM(S): Homo sapiens

2011-09-30 | E-MTAB-774 | biostudies-arrayexpress

An intramolecular hydrogen bond-promoted "green" Ugi cascade reaction for the synthesis of 2,5-diketopiperazines with anticancer activity.

Not available

S-EPMC9678023 | biostudies-literature

Loss of MiR-155 Sensitizes FLT3-ITD⁺AML to Chemotherapy and FLT3 Inhibitors via Glycolysis Blocking by Targeting PIK3R1.

Not available

S-EPMC9809327 | biostudies-literature

Downregulation of S6 Kinase and Hedgehog-Gli1 by Inhibition of Fatty Acid Synthase in AML with FLT3-ITD Mutation.

Not available

S-EPMC12193305 | biostudies-literature

BRD4 inhibitor reduces exhaustion and blocks terminal differentiation in CAR-T cells by modulating BATF and EGR1.