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MetabolomicsMedicarpin suppresses gastric cancer growth through modulation of mevalonate pathway-associated cholesterol biosynthesis
Background: Gastric cancer (GC) is an aggressive malignancy characterized by metabolic reprogramming, including dysregulated cholesterol biosynthesis. Medicarpin (Med), a natural isoflavan isolated from Radix Hedysari, has shown pharmacological potential; however, its anti-GC activity and metabolic ...
2026-10-02 | MTBLS15900 | MetaboLights
TranscriptomicsDifferential induction of apoptosis, IFN signaling and phagocytosis in macrophages infected with a panel of attenuated and non-attenuated poxviruses
Similarities as well as differences were found in macrophages infected with different virus strains, particularly at the expression level of immunomodulatory genes, but infection with MVA was particularly efficient in triggering changes in gene expression associated with increased activation of inna...
ORGANISM(S): Homo sapiens 
2016-03-14 | E-GEOD-79159 | biostudies-arrayexpress
UnknownA novel MVA-mediated pathway for isoprene production in engineered E. coli.
Not available
S-EPMC4719670 | biostudies-literature
GenomicsSingle-cell analysis reveals divergent responses of human dendritic cells to the MVA vaccine
Single-cell analysis reveals divergent responses of human dendritic cells to the MVA vaccine
PRJNA644334 | ENA
TranscriptomicsSingle-cell analysis reveals divergent responses of human dendritic cells to the MVA vaccine
Modified vaccinia Ankara (MVA) is a live, attenuated human smallpox vaccine and a vector for the development of new vaccines against infectious diseases and cancer. Efficient activation of the immune system by MVA partially relies on its encounter with dendritic cells (DCs). MVA infection of DCs lea...
ORGANISM(S): Homo sapiens 
2021-08-25 | GSE153835 | GEO
UnknownEnhancing production of bio-isoprene using hybrid MVA pathway and isoprene synthase in E. coli.
Not available
S-EPMC3338741 | biostudies-literature
UnknownSynthesis of cembratriene-ol and cembratriene-diol in yeast via the MVA pathway.
Not available
S-EPMC7852193 | biostudies-literature
GenomicsGene expression signature of TATA DNA binding mutant- spt15_A101T mutant (MVA pathway flux increasing mutant)
Gene expression signature of TATA DNA binding mutant- spt15_A101T mutant (MVA pathway flux increasing mutant)
PRJNA427185 | ENA
UnknownOptimizing the downstream MVA pathway using a combination optimization strategy to increase lycopene yield in Escherichia coli.
Not available
S-EPMC9208136 | biostudies-literature
ProteomicsThe proteomics sequencing of two engineered yeast strains CEN-Cho and CEN-Cho-MVA
An MS-based proteomics approach was utilized to monitor the changes in protein abundance between the CEN-Cho and CEN-Cho-mMVA. A total of 702 differently expressed proteins (DEPs) were identified in the comparison group.
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-08-24 | PXD074200 | Pride
Proteomics analysis 
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