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UnknownGenetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium.

Background

The large airway epithelial barrier provides one of the first lines of defense against respiratory viruses, including SARS-CoV-2 that causes COVID-19. Substantial inter-individual variability in individual disease courses is hypothesized to be partially mediated by the differentia...
S-EPMC8059115 | biostudies-literature
UnknownChromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices.
Autosomal genetic analyses of blood lipids have yielded key insights for coronary heart disease (CHD). However, X chromosome genetic variation is understudied for blood lipids in large sample sizes. We now analyze genetic and blood lipid data in a high-coverage whole X chromosome sequencing study of...
S-EPMC8042019 | biostudies-literature
UnknownInherited causes of clonal haematopoiesis in 97,691 whole genomes.
Age is the dominant risk factor for most chronic human diseases, but the mechanisms through which ageing confers this risk are largely unknown1. The age-related acquisition of somatic mutations that lead to clonal expansion in regenerating haematopoietic stem cell populations has recently...
S-EPMC7944936 | biostudies-literature
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