Inherited causes of clonal haematopoiesis in 97,691 whole genomes.

ABSTRACT: Age is the dominant risk factor for most chronic human diseases, but the mechanisms through which ageing confers this risk are largely unknown¹. The age-related acquisition of somatic mutations that lead to clonal expansion in regenerating haematopoietic stem cell populations has recently been associated with both haematological cancer^2-4 and coronary heart disease⁵-this phenomenon is termed clonal haematopoiesis of indeterminate potential (CHIP)⁶. Simultaneous analyses of germline and somatic whole-genome sequences provide the opportunity to identify root causes of CHIP. Here we analyse high-coverage whole-genome sequences from 97,691 participants of diverse ancestries in the National Heart, Lung, and Blood Institute Trans-omics for Precision Me

SUBMITTER: Bick AG 

PROVIDER: S-EPMC7944936 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature