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ProteomicsThe antiviral GTPase MxB is packaged into virions and binds via its N-terminal domain to alphaherpesvirus capsids
The interferon-inducible myxovirus resistance proteins belong to the dynamin-like GTPases, with MxA being a restriction factor against several RNA viruses, while MxB restricts infections of lentiviruses and herpesviruses. Humans express MxA(1-662) with an N-terminal domain (NTD) of 43 residues, MxB(...
ORGANISM(S): Homo sapiens (Human) 
2026-06-30 | PXD069031 | Pride
Herpes simplex virus Mxb Virion 
ProteomicsThe interferon-inducible antiviral GTPase MxB promotes capsid disassembly and genome release of herpesviruses
Host proteins sense viral products and induce defense mechanisms, particularly in immune cells. Using cell-free assays and quantitative mass spectrometry, we determined the interactomes of capsidhost protein complexes of herpes simplex virus, and identified the large dynamin-like GTPase myxovirus re...
ORGANISM(S): Homo sapiens (Human) Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) 
2022-05-06 | PXD028276 | Pride
Hsv1   mxb   host defense 
UnknownStructural insight into HIV-1 restriction by MxB.
Not available
S-EPMC4252739 | biostudies-literature
UnknownPro-515 of the dynamin-like GTPase MxB contributes to HIV-1 inhibition by regulating MxB oligomerization and binding to HIV-1 capsid.
Not available
S-EPMC7212661 | biostudies-literature
UnknownMxB inhibits long interspersed element type 1 retrotransposition.
Not available
S-EPMC8849481 | biostudies-literature
UnknownHIV-1 resists MxB inhibition of viral Rev protein.
Not available
S-EPMC7534208 | biostudies-literature
UnknownContribution of MxB oligomerization to HIV-1 capsid binding and restriction.
Not available
S-EPMC4337540 | biostudies-literature
UnknownHost and viral determinants for MxB restriction of HIV-1 infection.
Not available
S-EPMC4213484 | biostudies-literature
UnknownMxB is an interferon-induced restriction factor of human herpesviruses.
Not available
S-EPMC5958057 | biostudies-literature
UnknownRole of MxB in Alpha Interferon-Mediated Inhibition of HIV-1 Infection.
Not available
S-EPMC6096811 | biostudies-literature
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