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TranscriptomicsTranscription profiling of human primary tumors from patients with metastatic neuroblastoma lacking MYCN amplification
Metastatic neuroblastomas lacking amplification of the MYCN proto-oncogene vary in their clinical behavior. Those diagnosed before one year of age are least aggressive and those diagnosed after two years are most aggressive. To improve current risk stratification and gain insight into the biological...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-3446 | biostudies-arrayexpress
GenomicsEnhancer invasion shapes MYCN dependent transcriptional amplification in neuroblastoma
Enhancer invasion shapes MYCN dependent transcriptional amplification in neuroblastoma
PRJNA318035 | ENA
TranscriptomicsMYCN-MB with MYCN amplification
BACKGROUND Focal high-level amplifications of MYC define a subset of high-risk medulloblastoma patients. However, the prognostic role of MYCN oncogene amplification remains less clear. We aimed to evaluate the prognostic value of this alteration alone and in combination with biological modifiers in ...
ORGANISM(S): Homo sapiens 
2011-09-01 | GSE30530 | GEO
TranscriptomicsGenotyping by array of human neuroblastoma cell lines showing MYCN amplification as double minutes or homogeneously staining regions
SNP array profile of cell lines from solid tumors showing MYCN amplification as Double minutes (dmin) and homogeneously staining regions (hsr)
ORGANISM(S): Homo sapiens 
2010-05-25 | E-MEXP-2735 | biostudies-arrayexpress
TranscriptomicsFunctional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification.
Neuroblastoma is a pediatric tumor of the sympathetic nervous system. MYCN (V-myc myelocytomatosis viral-related oncogene, neuroblastoma derived [avian]) is amplified in 20% of neuroblastomas, and these tumors carry a poor prognosis. However, tumors without MYCN amplification also may have a poor ou...
ORGANISM(S): Homo sapiens 
2012-11-05 | GSE39218 | GEO
UnknownFunctional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification.
Not available
S-EPMC3511149 | biostudies-literature
GenomicsDirect Targeting of MYCN Gene Amplification by CRISPR/Cas9 in Neuroblastoma Cells (CHP-134)
Direct Targeting of MYCN Gene Amplification by CRISPR/Cas9 in Neuroblastoma Cells (CHP-134)
PRJNA497579 | ENA
TranscriptomicsEnhancer invasion shapes MYCN dependent transcriptional amplification in neuroblastoma [ATAC-seq]
In neuroblastoma, amplification of the oncogenic basic helix-loop-helix (bHLH) transcription factor (TF) MYCN is the defining prognosticator of high-risk disease, occurs in one-third of neuroblastoma, and drastically reduces overall survival rates1,2. As a proto-oncogene, targeted MYCN overexpressio...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-80152 | biostudies-arrayexpress
UnknownImplementation of the plasma MYCN/NAGK ratio to detect MYCN amplification in patients with neuroblastoma.
Not available
S-EPMC7607162 | biostudies-literature
UnknownMechanisms of embryonal tumor initiation: distinct roles for MycN expression and MYCN amplification.
Not available
S-EPMC515113 | biostudies-literature
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