Sort   by:  
 Page size 
TranscriptomicsComputational drug repositioning identifies niclosamide and tribromsalan as inhibitors of Mycobacterium tuberculosis and Mycobacterium abscessus
Tuberculosis (TB) is still a major global health challenge, killing over 1.5 million people each year, and hence, there is a need to identify and develop novel treatments for Mycobacterium tuberculosis (M. tuberculosis). The prevalence of infections caused by nontuberculous mycobacteria (NTM) is als...
ORGANISM(S): Mycobacterium tuberculosis 
2024-03-01 | E-MTAB-13761 | biostudies-arrayexpress
TranscriptomicsMntR(Rv2788): a transcriptional regulator that controls manganese homeostasis in Mycobacterium tuberculosis.
Transcriptional profiling of SirR and manganese regulated expression of genes in Mycobacterium tuberculosis strains comparing high manganese vs. low manganese in Rv (wild type Mycobacterium tuberculosis) and ST70 (mntR mutant strain of Mycobacterium tuberculosis) Two strains each with two conditions...
ORGANISM(S): Mycobacterium tuberculosis 
2015-12-08 | E-GEOD-70812 | biostudies-arrayexpress
TranscriptomicsTime course RNA-seq of Mycobacterium tuberculosis exposed to nitric oxide.
Mycobacterium tuberculosis is an intracellular human pathogen with the ability to resist and adapt to many adverse conditions it encounters upon infection. Among these, overcoming the production of nitric oxide by macrophages could be key for M. tuberculosis success. We have challenged M. tuberculo...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2017-08-29 | E-MTAB-5557 | biostudies-arrayexpress
ProteomicsThe Mycobacterium tuberculosis O-phosphorylation landscape
LC-MS/MS tryptic peptide data comprising both label free (phosphoproteome) and TMT10 (global and phosphoproteome) analysis of mycobacterium tuberculosis mutants (WT, GoF, and LoF) grown at stationary phase. Data was searched with MS-GF+ (TMT) and MaxQuant (label free).
ORGANISM(S): Mycobacterium Tuberculosis (ncbitaxon:1773) 
2021-10-21 | MSV000088254 | MassIVE
ProteomicsMycobacterium tuberculosis normoxia hypoxia reactivation with ActivX-desthiobiotin FP probe
Lysates of Mycobacterium tuberculosis (H37Rv auxotroph mc(2)6020) grown under various conditions (normoxia, hypoxia, reactivation from hypoxia) probed the serine hydrolase probe with ActivX-desthiobiotin FP.
ORGANISM(S): Mycobacterium Tuberculosis (ncbitaxon:1773) 
2016-10-10 | MSV000080238 | MassIVE
TranscriptomicsA Novel Gene Regulates Vesiculogenesis and Immunomodulation in Mycobacterium tuberculosis
After co-evolving with humans, its only major host, Mycobacterium tuberculosis (Mtb) restrains immune responses well enough to escape eradication, yet elicits enough immunopathology to ensure its transmission. Here, we provide evidence that this balance is regulated in part by a previously uncharact...
ORGANISM(S): Mus musculus 
2013-12-03 | E-GEOD-50050 | biostudies-arrayexpress
TranscriptomicsMycobacterium smegmatis: CarD depletion (mgm1703) vs Control (mgm1701)
Transcriptional profiling of Mycobacterium smegmatis comparing the effects of wild type levels of CarD expression with CarD depletion. Transcriptional profile of the mgm1701 control strain was compared with that of mgm1703, a strain where CarD transcription is regulated by a Tet-On system. Both stra...
ORGANISM(S): Mycobacterium smegmatis 
2010-05-16 | E-GEOD-15437 | biostudies-arrayexpress
TranscriptomicsComparison of mid-log transcriptomes of clinical isolates of Mycobacterium tuberculosis
The global diversity of Mycobacterium tuberculosis comprises at least seven lineages, each with its distinct geographic distribution. The aim of this experiment was to perform a comparative analysis of two of these lineages: Lineage 1 and Lineage 2. The former is found around the rim of the Indian ...
ORGANISM(S): Mycobacterium tuberculosis 
2020-12-31 | E-MTAB-8103 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of RelE family toxin overexpression in Mycobacterium tuberculosis
To understand the mechanism of action of the RelE family of toxins on metabolism of Mycobacterium tuberculosis. To this effect, toxin expression was induced under control of a tetracycline regulatable promoter and transcriptional profiles compared during overexpression of the three RelE toxin family...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-18 | E-GEOD-13998 | biostudies-arrayexpress
GenomicsHigh-resolution transcriptome and genome-wide dynamics of RNA polymerase and NusA in Mycobacterium tuberculosis (ChIP-seq)
To construct a regulatory map of the genome of the human pathogen, Mycobacterium tuberculosis, we applied two complementary high-resolution approaches, strand-specific RNA-seq and ChIP-seq, to survey the global transcriptome and monitor genome-wide dynamics of RNA polymerase (RNAP) and NusA. ChIP-s...
ORGANISM(S): Mycobacterium tuberculosis 
2012-12-01 | E-GEOD-40845 | biostudies-arrayexpress
Sort   by:  
 Page size