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TranscriptomicsAffymetrix SNP array data for Genomic Instability and Myelodysplasia with Monosomy 7
Gene modified autologous hematopoietic stem cells (HSC) can provide significant clinical benefits to patients suffering from X-linked chronic granulomatous disease (X-CGD), a rare inherited immunodeficiency characterized by recurrent, often life threatening bacterial and fungal infections. Here we...
ORGANISM(S): Homo sapiens 
2010-01-12 | E-GEOD-19523 | biostudies-arrayexpress
GenomicsTranscriptome sequencing of myelodysplasia
Transcriptome sequencing was performed on 214 patients with myelodysplasia in this study. RNA was obtained from bone marrow CD34+ cells (n=100) and/or bone marrow mononuclear cells (n=165). Transcriptome sequencing was performed for both cell fractions in 51 patients. We also studied bone marrow CD3...
EGAS00001002346 | EGA
TranscriptomicsAlpha Thalassaemia Myelodysplasia Syndrome (ATMDS)
A 10K cDNA microarray was used to compare granulocyte RNA from one ATMDS patient to pooled granulocyte RNA from 7 healthy controls.
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-445 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for myelodysplastic syndromes (MDS) and related neoplasms
In this study, to obtain a complete registry of genetic lesions in MDS and to identify novel therapeutic targets, we performed SNP array analysis and whole exome analysis for novel mutations using high-throughput sequencing technologies. In whole exome analysis, paired CD3-positive T cells were used...
ORGANISM(S): Homo sapiens 
2011-09-11 | E-GEOD-31174 | biostudies-arrayexpress
TranscriptomicsAltered Hematopoietic Cell Gene Expression Precedes Development of Therapy-Related Myelodysplasia and Identifies Patients at Risk
Therapy-related myelodysplasia or acute myeloid leukemia (t-MDS/AML) is a lethal complication of cancer treatment. Although t-MDS/AML development is associated with known genotoxic exposures, its pathogenesis is not well understood and methods to predict risk of development of t-MDS/AML in individua...
ORGANISM(S): Homo sapiens 
2011-12-12 | E-GEOD-23025 | biostudies-arrayexpress
TranscriptomicsIllumina GoldenGate Methylation array data for X-CGD patients and healthy controls
We report on the molecular and cellular events observed in two patients treated by gene therapy in 2004. After the initial resolution of bacterial and fungal infections, both patients exhibited silencing of transgene expression due to methylation of the viral promoter, and myelodysplasia with monoso...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-19515 | biostudies-arrayexpress
GenomicsEGAS00001000089-sc-20111014 - samples
Somatic mutation of SF3B1 in myelodysplasia with ring sideroblasts and other cancers
EGAD00001000045 | EGA
TranscriptomicsExpression analysis of mutant U2AF35 transduced cells
In this study, to obtain the biological impact of the mutated U2AF35, HeLa and TF-1 cells were retrovirally transduced with either mock, wild-type or S34F mutant of U2AF35, and Expression array was performed. Expression analysis was performed for mock, wild-type U2AF35 or S34F mutant transduced HeLa...
ORGANISM(S): Homo sapiens 
2011-09-11 | E-GEOD-31172 | biostudies-arrayexpress
Genomicsena-DATASET-CGP-UT-04-01-2018-02:12:18:566-617 - samples
Transcriptome sequencing was performed on 214 patients with myelodysplasia in this study. RNA was obtained from bone marrow CD34+ cells (n=100) and/or bone marrow mononuclear cells (n=165). Transcriptome sequencing was performed for both cell fractions in 51 patients. A total of 211 patients were ge...
EGAD00001003891 | EGA
UnknownThe miRNA Profile in Non-Hodgkin's Lymphoma Patients with Secondary Myelodysplasia.
Not available
S-EPMC7656297 | biostudies-literature
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