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UnknownComparing Measures Of Functional Difficulty With Self-Identified Disability: Implications For Health Policy.
Not available
S-EPMC10353341 | biostudies-literature
TranscriptomicsRNA-seq of micro RNAs (miRNAs) in Human prefrontal cortex to identify differentially expressed miRNAs between Huntington's Disease and control brain samples
To identify genome-wide differentially expressed microRNAs (miRNAs) between Huntington's disease (HD) and control Human pre-frontal cortex samples
ORGANISM(S): Homo sapiens 
2014-01-30 | E-MTAB-2206 | biostudies-arrayexpress
TranscriptomicsmRNA-Seq Expression profiling of human post-mortem BA9 brain tissue for Huntington's Disease and neurologically normal individuals
Huntington’s Disease (HD) is a devastating neurodegenerative disorder that is caused by an expanded CAG trinucleotide repeat in the Huntingtin (HTT) gene. Transcriptional dysregulation in the human HD brain has been documented but is incompletely understood. Here we present a genome-wide analysis ...
ORGANISM(S): Homo sapiens 
2015-12-08 | E-GEOD-64810 | biostudies-arrayexpress
UnknownDasatinib Plus Intensive Chemotherapy in Children, Adolescents, and Young Adults With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Results of Children's Oncology Group Trial AALL0622.
Not available
S-EPMC6067800 | biostudies-literature
GenomicsSevere acute respiratory syndrome coronavirus 2
Genomic epidemiology of SARS-CoV-2 in a UK university to identify dynamics of transmission
PRJNA779279 | ENA
TranscriptomicsRNA-Seq of A375 cells treated with tetracycline-based crosslinking probes, with and without competition by parent tetracyclines, to show specific binding of the tetracycline analogs Col-3 and doxycycline on rRNA substructures of the human ribosome
Upon finding that the tetracyclines COL-3 and doxycycline target unique rRNA substructures of the 80S ribosome (E-MTAB-7147), we confirmed these putative ribosomal binding sites by showing that tetracycline-based crosslinking probes are specifically competed from these rRNA structures by their paren...
ORGANISM(S): Homo sapiens 
2018-08-31 | E-MTAB-7161 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of A375 cells treated with tetracycline-based crosslinking probes to identify binding sites for the tetracycline analogs Col-3 and doxycycline on the human ribosome
Following the identification of the 80S ribosome as a putative target of the tetracycline analogs Col3 and doxycycline, we next sought to identify the precise binding sites for these tetracyclines within the ribonucleoprotein complex. We incorporated dual bioorthogonal handles into tetracycline-base...
ORGANISM(S): Homo sapiens 
2018-08-30 | E-MTAB-7147 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human melanoma cell line A375 treated with the tetracycline analogs Col-3 or doxycycline against untreated controls
Apart from their antibacterial activity, tetracyclines have demonstrated diverse and beneficial “off-target” biological activities in human disease, spurring interest in their development as non-antimicrobial therapeutics in diseases such as cancer. To better define biological pathways modified by t...
ORGANISM(S): Homo sapiens 
2018-09-01 | E-MTAB-7126 | biostudies-arrayexpress
TranscriptomicsmicroRNA profiles in Parkinsonâ??s disease prefrontal cortex
Objective. The goal of this study was to examine the microRNA (miRNA) profile of Parkinsonâ??s disease (PD) frontal cortex as compared to normal control brain, allowing for the identification of PD specific signatures as well as the study of disease-related phenotypes, such as onset age or dementia ...
ORGANISM(S): Homo sapiens 
2016-03-16 | E-GEOD-72962 | biostudies-arrayexpress
TranscriptomicsmiRNA-seq expression profiling of Huntington's Disease and neurologically normal human post-mortem prefrontal cortex (BA9) brain samples
BACKGROUND MicroRNAs (miRNAs) are small non-coding RNAs that recognize sites of complementarity of target messenger RNAs, resulting in transcriptional regulation and translational repression of target genes. In Huntington’s disease (HD), a neurodegenerative disease caused by a trinucleotide repeat e...
ORGANISM(S): Homo sapiens 
2015-03-12 | E-GEOD-64977 | biostudies-arrayexpress
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