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MetabolomicsThe dynamic changes and mechanism of no reflow injury after myocardial ischemia-reperfusion
This study aims to investigate the dynamic changes and correlation of no-reflow (NR) injury following myocardial ischemia and reperfusion, and to explore the underlying mechanism of NR injury through transcriptomic and metabolomic analysis. Methods: Healthy male SD rats were divided into two batches...
2026-08-25 | MTBLS15452 | MetaboLights
MetabolomicsMongolian medicine Wulanwendusu-11 ameliorates myocardial ischemia-reperfusion injury in association with the modulation of intestinal microbiota and associated metabolic pathways

Abstract

Objective: Wulanwendusu-11 (WLWDS-11), a traditional Mongolian medicinal formula, is commonly used for the treatment of Cardiovascular diseases. However, its therapeutic material basis and in vivo metabolic profile in the context of chronic myocardial ischemia-reperfusion injury (M...

2025-11-22 | MTBLS13370 | MetaboLights
MetabolomicsIntegrated transcriptomic and metabolomic analysis reveals the regulatory role of Itaconic acid in inflammatory infiltration during myocardial Ischemia-Reperfusion injury

Following establishment of a myocardial ischemia-reperfusion model, tissue samples from the infarct border zone were harvested for transcriptomics and wide-target metabolomic sequencing. Bioinformatics methods were used to analyse the transcriptomics and metabolomics results separately and to per...

2025-10-14 | MTBLS12934 | MetaboLights
MetabolomicsIntraoperative intestinal ischemia-reperfusion injury aggravates postoperative delirium by remodeling gut microbiota
Postoperative delirium, is a notable and serious complication after surgery, commonly extending hospitalization by 2-3 days. In a cohort of 167 patients, elevated serum intestinal fatty acid binding protein (I-FABP) was identified as an independent risk factor for postoperative delirium. Complementa...
2026-03-30 | MTBLS14186 | MetaboLights
TranscriptomicsRNA-seq of rat myocardial tissue to investigate the cardioprotective mechanism of baicalin in myocardial ischemia-reperfusion injury
This study aimed to investigate the cardioprotective mechanism of baicalin (BAI) against myocardial ischemia-reperfusion injury (MIRI) in rats. We performed RNA-seq on left ventricular myocardial tissue from three groups: Sham (vehicle control), I/R (ischemia-reperfusion injury model), and I/R+BAI (...
ORGANISM(S): Rattus norvegicus 
2026-07-31 | E-MTAB-17471 | biostudies-arrayexpress
TranscriptomicsCaM Kinase II mediates maladaptive post-infarct remodeling but not acute myocardial ischemia/reperfusion injury
Calcium/calmodulin-dependent protein kinase II (CaMKII) was suggested to mediate ischemic myocardial injury and adverse cardiac remodeling. However, the specific functions of the CaMKII isoforms and splice variants in ischemia/reperfusion (I/R) injury have not been investigated yet. Thus, we studied...
ORGANISM(S): Mus musculus 
2014-09-08 | E-GEOD-58486 | biostudies-arrayexpress
TranscriptomicsRNA microarray of rat kidney treated with or without silicon nano-particles against ischemia reperfusion injury
RNA microarray was performed to evaluate the efficacy of silicon nano-particles on renal transcriptomes of rats against ischemia reperfusion injury. We compared the transcriptomes of ischemia reperfusion injury model rats with or without oral administration of silicon nano-particles. We also tried t...
ORGANISM(S): Rattus norvegicus 
2020-02-04 | E-MTAB-8687 | biostudies-arrayexpress
MetabolomicsImpact of myocardial reperfusion on human plasma lipidome
The primary aim of the study is to investigate the temporal changes in plasma lipidome before and after reperfusion in patients with ST-segment elevation myocardial infarction (STEMI) and their association with myocardial injury. We found that 56% of the identified lipid species were significantly a...
2022-02-07 | MTBLS3839 | MetaboLights
MetabolomicsMetabolism Disorder Promotes Isoproterenol-induced Myocardial Injury in Mice with High Temperature and High Humidity and High-Fat Diet

Isoproterenol (ISO) provides a simple and non-invasive method for inducing myocardial injury with lower mortality and higher reproducibility. Phlegm-damp syndrome, as known as “Tanshi” in Chinese, is one of Traditional Chinese Medicine (TCM) syndrome differentiation, which plays an important role...

2022-01-10 | MTBLS3886 | MetaboLights
ProteomicsAnalysis of cardiac ischemia-reperfusion injury using DIA proteomics and N-terminomics
Data used in the publication: Analysis of cardiac ischemia-reperfusion injury using DIA proteomics and N-terminomics reveals alterations in mitochondrial function and metabolism
ORGANISM(S): Rattus (ncbitaxon:10114) 
MSV000092906 | MassIVE
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