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TranscriptomicsRNA-Seq of rat myocardial slices cultured with biomimetic electromechanical stimulation
Adult cardiac tissue undergoes a rapid process of dedifferentiation when cultured in vitro. The aim of this experiment was to compare the transcriptome of freshly prepared rat myocardial slices with slices cultured in unloaded conditions (no electromechanical stimulation) for 24 hours, electromecha...
ORGANISM(S): Rattus norvegicus 
2019-04-17 | E-MTAB-7842 | biostudies-arrayexpress
ProteomicsLabel-free quantitative SWATH-MS proteomic analysis of adult myocardial slices in vitro after biomimetic electromechanical stimulation
Conventional in vitro cell cultures are relatively available and have been widely used in explaining many mechanisms, but their simple construction is not directly applied to the in vivo environment. A possible solution to overcome this problem is special in vitro model maintained with cardiac slice...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-08-25 | PXD034891 | Pride
Rat Heart Myocardial slices Swath-ms 
GenomicsRNA-Seq of rat myocardial slices cultured with biomimetic electromechanical stimulation
RNA-Seq of rat myocardial slices cultured with biomimetic electromechanical stimulation
PRJEB32189 | ENA
GenomicsTotal RNA-seq of rat living myocardial slices (LMS) treated with aloxistiatin (E64d)
Total RNA-seq of rat living myocardial slices (LMS) treated with aloxistiatin (E64d)
PRJEB102531 | ENA
GenomicsEffect of ferrostatin-1 on living myocardial slices derived from heart failure patients
Effect of ferrostatin-1 on living myocardial slices derived from heart failure patients
PRJNA1019337 | ENA
UnknownInvestigation of cardiac fibroblasts using myocardial slices.
Not available
S-EPMC5852538 | biostudies-literature
TranscriptomicsTotal RNA-seq of rat living myocardial slices (LMS) treated with aloxistiatin (E64d)
This study aims to explore the therapeutic potential of the cysteine protease inhibitor aloxistatin (E64d) as a candidate to combat cardiac fibrotic progression. Rodent living myocardial slices (LMS) from left ventricular tissue were treated for 4h and 24h with aloxistatin (100µM) or DMSO control. F...
ORGANISM(S): Rattus norvegicus 
2026-07-06 | E-MTAB-16035 | biostudies-arrayexpress
UnknownBiomimetic electromechanical stimulation to maintain adult myocardial slices in vitro.
Not available
S-EPMC6520377 | biostudies-literature
TranscriptomicsProtective effect of UDCA against IL-11- induced cardiac fibrosis is mediated by TGR5 signalling
1.1 Introduction Cardiac fibrosis occurs in a wide range of cardiac diseases and is characterised by the transdifferentiation of cardiac fibroblasts into myofibroblasts these cells produce large quantities of extracellular matrix, resulting in myocardial scar. The profibrotic process is m...
ORGANISM(S): Homo sapiens 
2024-11-30 | E-MTAB-14602 | biostudies-arrayexpress
UnknownMicrotubule destabilization with colchicine increases the work output of myocardial slices.
Not available
S-EPMC10997380 | biostudies-literature
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