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MetabolomicsMetabolomics of heart tissue at baseline and following myocardial infarction
A comprehensive analysis of the heart metabolome was conducted at 60 min reperfusion post ischaemia. This analysis employed LC-MS/MS in order to provide a detailed examination of the metabolic processes occurring within the heart. The focus of this analysis was placed on glycolysis, the tricarboxyli...
2026-04-30 | MTBLS14417 | MetaboLights
MetabolomicsNon-targeted LC–MS metabolomics of human left atrial appendage tissue with high vs low myocardial micro(nano)plastic burden

Non-targeted metabolomics profiling was performed on human left atrial appendage tissue obtained from cardiac surgery patients. Samples were grouped by myocardial nanoplastic (NP) burden (High vs Low). Polar metabolites were analyzed by UHPLC–Orbitrap MS in both positive and negative ionization m...

2026-03-28 | MTBLS14056 | MetaboLights
MetabolomicsThe dynamic changes and mechanism of no reflow injury after myocardial ischemia-reperfusion
This study aims to investigate the dynamic changes and correlation of no-reflow (NR) injury following myocardial ischemia and reperfusion, and to explore the underlying mechanism of NR injury through transcriptomic and metabolomic analysis. Methods: Healthy male SD rats were divided into two batches...
2026-08-25 | MTBLS15452 | MetaboLights
MetabolomicsMRG15 orchestrates glycolysis and the pentose phosphate pathway to facilitate heart regeneration following myocardial infarction
Metabolic reprogramming is crucial for adult heart regeneration after myocardial infarction (MI). Here, we identify the MORF4-related gene on chromosome 15 (MRG15) as a key orchestrator of cardiomyocyte metabolism to drive cardiomyocyte proliferation. MRG15 expression is upregulated in both hypoxic ...
2026-09-22 | MTBLS15770 | MetaboLights
MetabolomicsMRG15 orchestrates glycolysis and the pentose phosphate pathway to facilitate heart regeneration following myocardial infarction
Metabolic reprogramming is crucial for adult heart regeneration after myocardial infarction (MI). Here, we identify the MORF4-related gene on chromosome 15 (MRG15) as a key orchestrator of cardiomyocyte metabolism to drive cardiomyocyte proliferation. MRG15 expression is upregulated in both hypoxic ...
2026-09-22 | MTBLS15769 | MetaboLights
MetabolomicsSCUBE3 enhances post-myocardial infarction angiogenesis by promoting endothelial fatty acid metabolism

BACKGROUND: Myocardial infarction (MI), one of the leading causes of mortality worldwide, remains a clinical challenge due to limitations in current therapeutic strategies. The cardiac vascular network, as the fundamental architecture sustaining myocardial function, delivers oxygen and nutrients ...

2025-09-18 | MTBLS13005 | MetaboLights
MetabolomicsSCUBE3 enhances post-myocardial infarction angiogenesis by promoting endothelial fatty acid metabolism.

BACKGROUND: Myocardial infarction (MI), one of the leading causes of mortality worldwide, remains a clinical challenge due to limitations in current therapeutic strategies. The cardiac vascular network, as the fundamental architecture sustaining myocardial function, delivers oxygen and nutrients ...

2025-09-18 | MTBLS13004 | MetaboLights
MetabolomicsCharacteristics of myocardial structure and central carbon metabolism during the early and compensatory stages of cardiac hypertrophy
Cardiac hypertrophy is a classical forerunner of heart failure and myocardial structural and metabolic remodeling are closely associated with cardiac hypertrophy. We aim to investigate the characteristics of myocardial structure and central carbon metabolism of cardiac hypertrophy at different stage...
2024-08-23 | MTBLS10555 | MetaboLights
MetabolomicsIntegrated transcriptomic and metabolomic analysis reveals the regulatory role of Itaconic acid in inflammatory infiltration during myocardial Ischemia-Reperfusion injury

Following establishment of a myocardial ischemia-reperfusion model, tissue samples from the infarct border zone were harvested for transcriptomics and wide-target metabolomic sequencing. Bioinformatics methods were used to analyse the transcriptomics and metabolomics results separately and to per...

2025-10-14 | MTBLS12934 | MetaboLights
MetabolomicsMetagenomics and Metabolomics Integrated to Explore the Protective Mechanisms of Mongolian Medicine Zadi-5 in Myocardial Ischemic Model Rats

Myocardial ischemia(MI) is a pathological state of abnormal energy metabolism due to insufficient blood and oxygen supply to the coronary arteries. The 'gut-heart axis' theory plays an important role in myocardial ischemia occurrence, mechanism, prevention, and cure. Traditional Mongolian medicin...

2026-01-27 | MTBLS13780 | MetaboLights
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