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TranscriptomicsSenescent and myofibroblastic cancer-associated fibroblasts share a contractile phenotype regulated by NOX4 generation of reactive oxygen species in the tumour microenvironment
Cancer associated fibroblasts characterized by an myofibroblastic phenotype play a major role in the tumour microenvironment, being associated with poor prognosis. We found that this cell population is made in part by senescent fibroblasts in vivo. As senescent fibroblasts and myofibroblasts have be...
ORGANISM(S): Homo sapiens 
2017-06-01 | E-MTAB-3101 | biostudies-arrayexpress
TranscriptomicsTranscriptomic Changes in TGF-β1 Differentiated and PGE2 Dedifferentiated Myofibroblasts
These data show that the genes that distinguish myofibroblasts from fibroblasts are myriad, and that some genes not traditionally associated with myofibroblast differentiation may serve as novel therapeutic targets for fibrosing disorders. Gene expression levels were assessed from total RNA on the A...
ORGANISM(S): Homo sapiens 
2015-06-30 | E-GEOD-63659 | biostudies-arrayexpress
TranscriptomicsReversible and irreversible differentiation of cardiac fibroblasts
Aim: Differentiation of cardiac fibroblasts (Fb) into myofibroblasts (MyoFb) is responsible for connective tissue buildup in myocardial remodeling. We examined reversibility of MyoFb differentiation. Methods and Results: Adult rat cardiac Fb were cultured on a plastic substratum providing mechanical...
ORGANISM(S): Rattus norvegicus 
2014-01-07 | E-GEOD-51824 | biostudies-arrayexpress
GenomicsEngrailed 1 coordinates cytoskeletal re-organization to induce myofibroblast differentiation
Engrailed 1 coordinates cytoskeletal re-organization to induce myofibroblast differentiation
PRJNA730706 | ENA
GenomicsEngrailed 1 coordinates cytoskeletal re-organization to induce myofibroblast differentiation
Engrailed 1 coordinates cytoskeletal re-organization to induce myofibroblast differentiation
PRJNA730572 | ENA
UnknownTelomerase regulation of myofibroblast differentiation.
Not available
S-EPMC2644224 | biostudies-literature
TranscriptomicsTranscription profiling of mouse primary cultures from mouse cornea vs those of the adult and 10-day postnatal mouse cornea to elucidate biological processes underlying the keratocyte, fibroblast, and myofibroblast phenotypes of corneal stromal cells
To elucidate biological processes underlying the keratocyte, fibroblast, and myofibroblast phenotypes of corneal stromal cells, the gene expression patterns of these primary cultures from mouse cornea were compared with those of the adult and 10-day postnatal mouse cornea.
ORGANISM(S): Mus musculus 
2007-10-31 | E-GEOD-1867 | biostudies-arrayexpress
UnknownProteasome activator PA200 regulates myofibroblast differentiation.
Not available
S-EPMC6811633 | biostudies-literature
UnknownDasatinib inhibits TGFβ-induced myofibroblast differentiation through Src-SRF Pathway.
Not available
S-EPMC4679708 | biostudies-literature
UnknownEnhanced myofibroblast differentiation of eMSCs in intrauterine adhesions.
Not available
S-EPMC11792338 | biostudies-literature
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