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As a group, fibroproliferative disorders of the lung, liver, kidney, heart, vasculature and integument are common, progressive and refractory to therapy. They can emerge following toxic insults, but are frequently idiopathic. Their enigmatic propensity to resist therapy and progress to organ failure...
ORGANISM(S): Homo sapiens 
Cancer-associated fibroblasts are a major component of the cancer stroma. Here we focus on gastric cancer associated myofibroblasts (CAMs). CAMs secrete factors that increase the migration, invasion and proliferation of cancer cells when compared to adjacent tissue myofibroblasts (ATMs), or normal t...
ORGANISM(S): Homo sapiens (Human) 
2019-03-04 | PXD008104 | Pride
Neuronal, endocrine and exocrine cells exhibit regulated exocytosis but there is also a body of evidence for regulated exocytosis from other cell types. Myofibroblasts are a stromal cell type that secretes extracellular matrix proteins, growth factors and cytokines; they are important in wound heali...
ORGANISM(S): Homo sapiens 
All samples are conditioned media from primary cultured human gastric myofibroblasts, derived from either carcinoma tissue, or adjacent non cancerous tissue. In each experiment the cancer-derived myofibroblasts are compared against the non-cancer derived myofibroblasts from the same patient. All of...
ORGANISM(S): Homo sapiens (Human) 
2013-06-20 | PRD000744 | Pride
We prepared miRNA from myofibroblats derived from normal oesophagus and esophageal cancers. miRCURYTM LNA Array ver5 was performed and comparisons were made by the dual (reference) method. Briefly, we have myofibroblast (NTM) from normal stomach and oesophagus, and we would like to establish whethe...
ORGANISM(S): Homo sapiens 
RNA sequencing of human esophageal myofibroblasts
Pericryptal myofibroblasts in the colon and rectum play an important role in regulating the normal colorectal stem cell niche and facilitating tumour progression. Myofibroblasts have previously mostly been distinguished from normal fibroblasts only by the expression of α smooth muscle actin (αSMA)...
ORGANISM(S): Homo sapiens 
Gene Expression Profiling of Gastric Cancer-Associated Myofibroblasts
Nuclear mechanosensing drives chromatin remodeling of persistently activated myofibroblasts
Expression data from cardiac myofibroblasts treated with siControl or siVgll3
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