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Proteomicsroad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathy
Myosin inhibitor mavacamten is the first targeted treatment available for hypertrophic cardiomyopathy (HCM), a disease caused by hundreds of genetic variants that affect mainly sarcomeric myosin and its negative regulator cardiac myosin-binding protein C (cMyBP-C, encoded by MYBPC3). Here, we have ...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-02 | PXD076207 | Pride
Hypertrophic cardiomyopathy Myosin inhibition 
TranscriptomicsRNP immunoprecipitation of fission yeast using Rng3p myosin-specific chaperones to investigate if the association of Rng3p with RNAs occurs on ribosomes
Ribonucleoprotein immunoprecipitation microarray (RIp-chip) study using the Rng3p myosin-specific chaperones from the fission Schizosaccaromyces pombe. Rng3p associates with RNAs encoding myosins. To investigate if the association of Rng3p with these RNAs occurs on ribosomes, Rng3-purified fractio...
ORGANISM(S): Schizosaccharomyces pombe 
2008-12-23 | E-TABM-564 | biostudies-arrayexpress
TranscriptomicsRibonucleoprotein immunoprecipitation of fission yeast to study myosin proteins and other cytoskeletal components
Ribonucleoprotein immunoprecipitation microarray (RIp-chip) study using various myosin proteins and other cytoskeletal components from the fission Schizosaccaromyces pombe
ORGANISM(S): Schizosaccharomyces pombe 
2009-09-01 | E-TABM-656 | biostudies-arrayexpress
ProteomicsKH_dKO: Simultaneous loss of skeletal muscle myosin heavy chain IIx and IIb causes severe hypoplasia of skeletal muscles in young mice
Simultaneous loss of skeletal muscle myosin heavy chain IIx and IIb causes severe hypoplasia of skeletal muscles in young mice
ORGANISM(S): Mus Musculus (mouse) 
2022-11-28 | PXD032244 | JPOST Repository
ProteomicsStudy of endogenous interactome of Myosin VI
Immunoprecipitation of endogenous Myosin VI in Human Cell Lines (Caco-2, HeLa, MCF10A, MDA-MB-231) and identification of true interactors by mass spectrometry
ORGANISM(S): Homo sapiens (Human) 
2021-07-08 | PXD026697 | Pride
Myosin vi Mcf 10a Hela Mda-mb-231 Caco-2 
ProteomicsUnusual cardiac myosin heavy chain post-translational modifications with systolic heart failure
In the present study, we aimed at defining whether cardiac myosin heavy chain (MYH7) post-translational modifications would be altered in systolic heart failure. For that, we had access to septal tissue from donors and from patients with non-genetic dilated cardiomyopathy or with ischemic cardiomyop...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD076695 | Pride
Heart failure  systolic dysfunction  myh7  myosin 
ProteomicsMavacamten inhibits myosin activity by stabilising the myosin interacting-heads motif and stalling motor force generation
Most sudden cardiac deaths in young people arise from hypertrophic cardiomyopathy, a genetic disease of the heart muscle, with many causative mutations found in the molecular motor beta-cardiac myosin that drives contraction. Therapeutic intervention for hypertrophic cardiomyopathy has until recentl...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-03-26 | PXD059316 | Pride
Dsbu Skyline Cardiac myosin Quantitative crosslinking ms 
ProteomicsNuclear myosin VI maintains replication fork stability
The actin cytoskeleton is of fundamental importance for cellular structure and plasticity. However, abundance and function of filamentous (F-) actin in the nucleus are still controversial. Here we show that the actin-based molecular motor myosin VI contributes to the stabilization of stalled or reve...
ORGANISM(S): Homo sapiens (Human) 
2023-05-04 | PXD035394 | Pride
Myosin vi Wrnip1 Darpins Fork stability Dna replication stress 
TranscriptomicsRibonucleoprotein immunoprecipitation of myosin proteins and myosin-specific chaperones in fission yeast
Ribonucleoprotein immunoprecipitation microarray (RIp-chip) study using various myosin proteins and myosin-specific chaperones from the fission Schizosaccaromyces pombe
ORGANISM(S): Schizosaccharomyces pombe 
2010-03-01 | E-TABM-335 | biostudies-arrayexpress
ProteomicsIdentification of cardiac myosin heavy chain post-translational modifications in hibernating grizzly bears
Mammal hibernation is a physiological process with unclear molecular mechanisms. Here, we aimed to investigate whether cardiac myosin heavy chain post-translational modifications would be affected by hibernation. For that, we used cardiac left ventricle specimens from active and hibernating adult gr...
ORGANISM(S): Ursus arctos (Brown bear) (Grizzly bear) 
2025-05-07 | PXD054499 | Pride
Bear Ptm Myosin 
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