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Proteomicsroad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathy
Myosin inhibitor mavacamten is the first targeted treatment available for hypertrophic cardiomyopathy (HCM), a disease caused by hundreds of genetic variants that affect mainly sarcomeric myosin and its negative regulator cardiac myosin-binding protein C (cMyBP-C, encoded by MYBPC3). Here, we have ...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-02 | PXD076207 | Pride
Hypertrophic cardiomyopathy Myosin inhibition 
GenomicsBroad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathy [RNASeq_LSM]
Broad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathy [RNASeq_LSM]
PRJNA1446799 | ENA
GenomicsBroad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathy [RNASeq_MAVA]
Broad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathy [RNASeq_MAVA]
PRJNA1446804 | ENA
ProteomicsCardiomyocyte external mechanical unloading activates modifications of alpha-actinin differently from sarcomere-originated unloading
Loss of myocardial mass in a neonatal rat cardiomyocyte culture is studied to determine whether there is a distinguishable cellular response based on the origin of mechano-signals. The approach herein compares the sarcomeric assembly and disassembly processes in heart cells by imposing mechano-signa...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2023-01-05 | MSV000091010 | MassIVE
ProteomicsHow Myosin VI Traps its Off-State, is Activated and Dimerizes
Myosin VI (Myo6) is the only minus-end directed nanomotor on actin, allowing it to uniquely contribute to numerous cellular functions. As for other nanomotors, proper functioning of Myo6 relies on precise spatio-temporal control of motor activity via a poorly defined off-state and interactions with ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD044767 | Pride
Myosin vi Human Clms Cross linking mass spectromety 
TranscriptomicsBroad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathy [RNASeq_LSM]
Myosin inhibitor mavacamten is the first targeted treatment available for hypertrophic cardiomyopathy (HCM), a disease caused by hundreds of genetic variants that affect mainly sarcomeric myosin and its negative regulator cardiac myosin-binding protein C (cMyBP-C, encoded by MYBPC3). Here, we have e...
ORGANISM(S): Mus musculus 
2026-06-02 | GSE326721 | GEO
TranscriptomicsBroad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathy [RNASeq_MAVA]
Myosin inhibitor mavacamten is the first targeted treatment available for hypertrophic cardiomyopathy (HCM), a disease caused by hundreds of genetic variants that affect mainly sarcomeric myosin and its negative regulator cardiac myosin-binding protein C (cMyBP-C, encoded by MYBPC3). Here, we have e...
ORGANISM(S): Mus musculus 
2026-06-02 | GSE326720 | GEO
GenomicsRNA-seq of murine cytotoxic T lymphocytes in response to myosin IIA inhibition using para-nitroblebbistatin
RNA-seq of murine cytotoxic T lymphocytes in response to myosin IIA inhibition using para-nitroblebbistatin
PRJEB82067 | ENA
TranscriptomicsTranscription profiling of Arabidopsis with post-transcriptionally silenced Myosin XI-K
This study was aimed to determine roles of individual myosins in organelle trafficking in plant cell. Expression of Myosin XI-K was suppressed in transgenic A.thaliana by using RNAi approach. To ensure that the RNAi-induced gene silencing was specific and did not affect expression of other myosins,...
ORGANISM(S): Arabidopsis thaliana 
2008-06-13 | E-GEOD-5431 | biostudies-arrayexpress
ProteomicsDysregulation of muscle myosin biochemical states in X-linked myotubular myopathy
Pathogenic variants in MTM1 are associated with a severe, congenital muscle disorder called X-linked myotubular myopathy. Here, we aimed to assess the effect of mavacamten (myosin ATPase inhibitor) treatment in a mouse model for X-linked myotubular myopathy (Mtm1-KO) using the global untargeted prot...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-31 | PXD068387 | Pride
Skeletal muscle  myotubular myopathy  mtm1  myosin 
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