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UnknownAging-affiliated post-translational modifications of skeletal muscle myosin affect biochemical properties, myofibril structure, muscle function, and proteostasis.
Not available
S-EPMC11296117 | biostudies-literature
UnknownOptogenetic induction of mechanical muscle stress identifies myosin regulatory ubiquitin ligase NHL-1 in C. elegans.
Not available
S-EPMC11317515 | biostudies-literature
ProteomicsUNC-45 assisted myosin folding depends on a conserved FX3HY motif implicated in Freeman Sheldon Syndrome
Myosin motors are critical for diverse motility functions ranging from cytokinesis and endocytosis to muscle contraction. The UNC-45 chaperone controls myosin function mediating the folding, assembly, and degradation of the muscle protein. Here, we analyze the molecular mechanism of UNC-45 as a hub ...
ORGANISM(S): Caenorhabditis elegans 
2024-07-25 | PXD040428 | Pride
Ufd-2 Myopathy Mhc-b Myo4 Protein quality control Crosslinking mass spectrometry Ubiquitin proteasome system Unc-45 Molecular chaperones Myosin proteostasis 
UnknownTranscriptional programming of translation by BCL6 controls skeletal muscle proteostasis.
Not available
S-EPMC10949880 | biostudies-literature
UnknownMyosin storage myopathy mutations yield defective myosin filament assembly in vitro and disrupted myofibrillar structure and function in vivo.
Not available
S-EPMC5886249 | biostudies-literature
TranscriptomicsWhole worm transcriptomics after optogenetically induced mechanical muscle stress (OptIMMuS)
Mechanical stress during muscle contraction is a constant threat to proteome integrity. Experimental systems are needed to identify proteostasis regulators that are critical under mechanical stress conditions. Although Caenorhabditis elegans combines the advantages of existing organismal and cell cu...
ORGANISM(S): Caenorhabditis elegans 
2024-07-16 | GSE241906 | GEO
UnknownHSC70 is a chaperone for wild-type and mutant cardiac myosin binding protein C.
Not available
S-EPMC6124431 | biostudies-literature
TranscriptomicsLet-7 coordinately suppresses components of the amino acid sensing pathway to induce autophagy
Macroautophagy (hereafter autophagy) is the major pathway by which macromolecules and organelles are degraded. Autophagy is regulated by the mTOR signaling pathway, which is the focal point for integration of metabolic information, with mTORC1 playing a central role in balancing biosynthesis and cat...
ORGANISM(S): Mus musculus 
2015-08-03 | E-GEOD-60452 | biostudies-arrayexpress
UnknownUFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins.
Not available
S-EPMC5797217 | biostudies-literature
UnknownChallenging muscle homeostasis uncovers novel chaperone interactions in Caenorhabditis elegans.
Not available
S-EPMC4428482 | biostudies-literature
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