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MetabolomicsEffect of Genetically Reduced Maternal Myostatin on Late Gestation Maternal, Fetal, and Placental Metabolomes in Mice.
Myostatin (gene symbol: Mstn) is an autocrine and paracrine inhibitor of muscle growth. Pregnant mice with genetically reduced levels of myostatin give birth to offspring with greater adult muscle mass and bone biomechanical strength. However, maternal myostatin is not detectable in fetal cir...
2023-06-08 | MTBLS3345 | MetaboLights
TranscriptomicsMuscle Hypertrophy Induced by Myostatin Inhibition Accelerates Degeneration in Dysferlinopathy
Because myostatin normally limits skeletal muscle growth, there is an extensive effort to develop myostatin inhibitors for clinical use. One potential concern is that in patients with muscle degenerative diseases, inducing hypertrophy may increase stress on dystrophic fibers. Here, we show that bl...
ORGANISM(S): Mus musculus 
2015-09-04 | E-GEOD-62945 | biostudies-arrayexpress
TranscriptomicsIdentification of target genes of myostatin loss-of-function in the muscle of bovine fetuses
Myostatin is a highly conserved Transforming Growth Factor beta family member which negatively regulates muscle development. Double-muscled (DM) cattle have a loss-of-function mutation in their myostatin gene responsible for a hypermuscular phenotype mainly due to hyperplasia. Thus these animals rep...
ORGANISM(S): Bos taurus 
2010-07-01 | E-GEOD-5456 | biostudies-arrayexpress
TranscriptomicsThe transcriptomic signature of myostatin inhibitory influence on the differentiation of mouse C2C12 myoblasts
GDF8 (myostatin) is a unique cytokine strongly affecting the skeletal muscle phenotype in human and animals. The aim of the present study was to elucidate the molecular mechanism of myostatin influence on the differentiation of mouse C2C12 myoblasts, using the global-transcriptome analysis with the ...
ORGANISM(S): Mus musculus 
2014-07-23 | E-GEOD-59674 | biostudies-arrayexpress
TranscriptomicsAdult cardiomyocyte specific loss of myostatin
Inhibition of myostatin signaling induces strong skeletal muscle growth making it an attractive target to treat muscle wasting and sarcopenia. However, the biological function of myostatin in the heart is barely understood. We demonstrate that conditional inactivation of myostatin in the adult murin...
ORGANISM(S): Mus musculus 
2014-05-16 | E-MEXP-3744 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse skeletal muscle gene expression after myostatin knockout in mature animals
RNA from 5 mice with postdevelopmental knockout of myostatin and 5 mice with normal myostatin expression was analyzed with comprehensive oligonucleotide microarrays. Myostatin depletion affected the expression of several hundred genes at nominal P < 0.01, but fewer than a hundred effects were statis...
ORGANISM(S): Mus musculus 
2009-03-28 | E-GEOD-15349 | biostudies-arrayexpress
TranscriptomicsTibialis anterior muscle of myostatin null mice treated with clenbuterol
Transcription profiling of skeletal muscle (tibialis anterior) of 5-week-old male wild type and myostatin null mice given ad libitum access to 20ppm clenbuterol hydrochloride in drinking water or plain tap water for 2 weeks. The objective of the study was to determine overlap in the mechanisms of mu...
ORGANISM(S): Mus musculus 
2014-02-03 | E-GEOD-27577 | biostudies-arrayexpress
TranscriptomicsEffects of wheel running exercise and myostatin depletion on skeletal muscle gene expression in mice
This SuperSeries is composed of the following subset Series: GSE31839: Effect of wheel running exercise and myostatin depletion on gene expression in triceps brachii muscles of mice GSE31843: Effect of wheel running exercise on gene expression in skeletal muscles of mice Refer to individual Series
ORGANISM(S): Mus musculus 
2011-09-02 | E-GEOD-31844 | biostudies-arrayexpress
ProteomicsMyostatin Deficiency But Not Anti-Myostatin Blockade Induces Marked Proteomic Changes in Mouse Skeletal Muscle
Recent studies have reported the deleterious physiological and metabolic changes in Mstn-/- mice including impaired force generation and susceptibility to contraction-induced injury. Such observations have raised the concerns about the functional quality of the increased muscle resulting from thera...
ORGANISM(S): Mus musculus (Mouse) 
2016-05-31 | PXD003747 | Pride
Myostatin knockout Silac mouse Gastrocnemius Quantitative proteomics Anti-myostatin blocking antibody 
TranscriptomicsDifferential miroRNA expression in myostatin knockout mice
To identify microRNAs involved in myostatin-deficient muscular hypertrophy, we compared miRNA expression in wild-type and myostatin knockout mice. Total RNA, isolated from three wild-type or myostatin knockout mice, was pooled and then used for microarray analysis.
ORGANISM(S): Mus musculus 
2013-12-17 | E-GEOD-49523 | biostudies-arrayexpress
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