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ProteomicsHierarchical small molecule inhibition of MYST acetyltransferases
MYST lysine acetyltransferases (KATs) is a class of epigenetic enzymes critical for cellular function that constitute an emerging therapeutic target in cancer. Recently, several drug-like MYST inhibitors have been reported that show promise in a variety of preclinical models as well as in clinical t...
ORGANISM(S): Homo sapiens (Human) 
2026-06-01 | PXD074488 | Pride
Histone acetylation Lysine acetyltransferases Wm-1119 Wm-3835 Drug-like myst inhibitors Chemoproteomics Myst Foxk2 Pf-9363 Wm-8014 
GenomicsChIP-seq of MYST acetyltransferases
Histone acetyltransferases (HAT) assemble into multisubunit complexes in order to target distinct lysine residues on nucleosomal histones. Here, we characterize native HAT complexes assembled by the BRPF-family of scaffold proteins. Their PHD-ZnKnuckle-PHD domain is essential for binding chromatin...
ORGANISM(S): Homo sapiens 
2013-10-09 | E-GEOD-47190 | biostudies-arrayexpress
GenomicsMYST acetyltransferases are a targetable therapeutic vulnerability in SETBP1-mutant leukemia [RNA-Seq]
MYST acetyltransferases are a targetable therapeutic vulnerability in SETBP1-mutant leukemia [RNA-Seq]
PRJNA1295953 | ENA
GenomicsMYST acetyltransferases are a targetable therapeutic vulnerability in SETBP1-mutant leukemia [CUT&Run]
MYST acetyltransferases are a targetable therapeutic vulnerability in SETBP1-mutant leukemia [CUT&Run]
PRJNA1295944 | ENA
UnknownHierarchical small molecule inhibition of MYST acetyltransferases.
Not available
S-EPMC12478385 | biostudies-literature
GenomicsChIP-seq of MYST acetyltransferases in RKO cell line
Genome-wide mapping of MYST acetyltransferase subunit BRPF3 in RKO synchronised cells. Genome-wide mapping of MYST acetyltransferase subunit BRPF3 in RKO synchronised cells.
ORGANISM(S): Homo sapiens 
2016-02-05 | E-GEOD-63722 | biostudies-arrayexpress
UnknownAutoacetylation of the MYST lysine acetyltransferase MOF protein.
Not available
S-EPMC3471714 | biostudies-literature
UnknownMYST protein acetyltransferase activity requires active site lysine autoacetylation.
Not available
S-EPMC3252582 | biostudies-literature
UnknownCatalytic mechanism of a MYST family histone acetyltransferase.
Not available
S-EPMC2752042 | biostudies-literature
UnknownThe MYST histone acetyltransferases are essential for gametophyte development in Arabidopsis.
Not available
S-EPMC2606689 | biostudies-literature
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