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MetabolomicsOmega-3 polyunsaturated fatty acids modulate gut microbiota-derived 18β-glycyrrhetinic acid to alleviate type 1 diabetes mellitus_fecal_Omega-3 PUFAs

Background

Omega-3 polyunsaturated fatty acids (PUFAs) are known to protect against type 1 diabetes mellitus (T1DM), but how they act through the gut-islet axis is not fully understood. This study explored how Omega-3 PUFA-influenced gut microbiota and their metabolites help protect pancrea...

2026-06-13 | MTBLS13979 | MetaboLights
GenomicsMaternal n-3 PUFAs deficiency regulates gene expression profile in microglia at P21 in offspring
Maternal n-3 PUFAs deficiency regulates gene expression profile in microglia at P21 in offspring
PRJNA664213 | ENA
TranscriptomicsMaternal n-3 PUFAs deficiency regulates gene expression profile in microglia at P21 in offspring
Maternal n-3 polyunsaturated fatty acids (PUFAs) deficiency modulates microglia transcriptional phenotypes and functions. We identified a specific n-3 PUFA-dependent signature of microglia at weaning during mouse brain development. MG550 custom-design NanoString chip was used to identify n-3 PUFAs d...
ORGANISM(S): Mus musculus 
2020-10-20 | GSE158181 | GEO
TranscriptomicsTranscription profiling of cultured rat cardiomyocytes grown with eicosapentaenoic acid or docosahexaenoic acid supplementation in the culture media
Despite the recognized protective effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in cardiovascular diseases, and the demonstration of the control of gene expression by polyunsaturated fatty acids (PUFAs), the effects of these n-3 fatty acids on the whole genoma has never been ...
ORGANISM(S): Rattus norvegicus 
2008-05-07 | E-GEOD-4327 | biostudies-arrayexpress
GenomicsTranscriptomic effects of dietary PUFAs in mouse dendritic cells
Transcriptomic effects of dietary PUFAs in mouse dendritic cells
PRJNA1238318 | ENA
UnknownSupplementation of n-3 PUFAs in Adulthood Attenuated Susceptibility to Pentylenetetrazol Induced Epilepsy in Mice Fed with n-3 PUFAs Deficient Diet in Early Life.
Not available
S-EPMC10305078 | biostudies-literature
UnknownEffects of Fish n-3 PUFAs on Intestinal Microbiota and Immune System.
Not available
S-EPMC6627897 | biostudies-literature
TranscriptomicsTranscription profiling of two human colon cancer cell lines treated with n-3 PUFA docosahexaenoic acid for 3 different time points
Several studies indicate that omega (n)-3 fatty acids may have a potential in the prevention and treatment of cancer. In this study the colon cancer cell lines SW480 and SW620 were treated with the n-3 PUFA DHA (Docosahexaenoic acid) for 3 different time points (12, 24 and 48h). The experiments were...
ORGANISM(S): Homo sapiens 
2008-04-01 | E-MEXP-1014 | biostudies-arrayexpress
UnknownEffect of High Ratio of n-6/n-3 PUFAs on Depression: A Meta-Analysis of Prospective Studies.
Not available
S-EPMC9164255 | biostudies-literature
TranscriptomicsTranscriptomic effects of dietary PUFAs in mouse dendritic cells
The immune system is shaped by the balance of n-3 and n-6 polyunsaturated fatty acids (PUFAs), but how these dietary lipids influence dendritic cells (DCs)— key inducers of adaptive immunity—remains largely unexplored. Importantly, whether an excess of n-6 PUFAs, a hallmark of modern diets, could un...
ORGANISM(S): Mus musculus 
2026-02-26 | GSE292400 | GEO
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