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ProteomicsDiscovery of Tamoxifen and N-Desmethyl Tamoxifen Protein Targets in MCF-7 Cells Using Large-Scale Protein Folding and Stability Measurements, part 2
The proteins in an MCF-7 cell line were probed for tamoxifen (TAM) and n-desmethyl tamoxifen (NDT) induced stability changes using the Stability of Proteins from Rates of Oxidation (SPROX) technique in combination with two different quantitative proteomics strategies. Together the SILAC- and iTRAQ-S...
ORGANISM(S): Homo sapiens (Human) 
2019-11-08 | PXD006747 | Pride
Tamoxifen Sprox N-desmethyl tamoxifen 
ProteomicsDiscovery of Tamoxifen and N-Desmethyl Tamoxifen Protein Targets in MCF-7 Cells Using Large-Scale Protein Folding and Stability Measurements
The proteins in an MCF-7 cell line were probed for tamoxifen (TAM) and n-desmethyl tamoxifen (NDT) induced stability changes using the Stability of Proteins from Rates of Oxidation (SPROX) technique in combination with two different quantitative proteomics strategies. Together the SILAC- and iTRAQ-S...
ORGANISM(S): Homo sapiens (Human) 
2019-11-08 | PXD006732 | Pride
Silac Tamoxifen Sprox Mcf-7 N-desmethyl tamoxifen 
TranscriptomicsGenotoxic, epigenetic, and transcriptomic effects of tamoxifen in mouse liver
Tamoxifen is a non-steroidal anti-estrogenic drug widely used for the treatment and prevention of breast cancer in women; however, there is evidence that tamoxifen is hepatocarcinogenic in rats, but not in mice. Additionally, it has been reported that tamoxifen may cause non-alcoholic fatty liver di...
ORGANISM(S): Mus musculus 
2014-10-11 | E-GEOD-62267 | biostudies-arrayexpress
UnknownSimplified phenotyping of CYP2D6 for tamoxifen treatment using the N-desmethyl-tamoxifen/ endoxifen ratio.
Not available
S-EPMC7653100 | biostudies-literature
UnknownDiscovery of Tamoxifen and N-Desmethyl Tamoxifen Protein Targets in MCF-7 Cells Using Large-Scale Protein Folding and Stability Measurements.
Not available
S-EPMC5695045 | biostudies-literature
UnknownEffect of CYP3A4*22, CYP3A5*3, and CYP3A combined genotypes on tamoxifen metabolism.
Not available
S-EPMC5684327 | biostudies-literature
UnknownClinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and Tamoxifen Therapy.
Not available
S-EPMC5931215 | biostudies-literature
UnknownTamoxifen in horses: pharmacokinetics and safety study.
Not available
S-EPMC6587269 | biostudies-literature
UnknownPharmacogenetics and pharmacokinetics of tamoxifen in a Zimbabwean breast cancer cohort.
Not available
S-EPMC10529681 | biostudies-literature
UnknownRelationship between genotypes Sult1a2 and Cyp2d6 and tamoxifen metabolism in breast cancer patients.
Not available
S-EPMC3726442 | biostudies-literature
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