Sort   by:  
 Page size 
TranscriptomicsGene expression in liver of wild-type and Dicer1-KO mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea
To explore the possible changes of gene expression induced by a carcinogen, we treated wild-type and Dicer1-KO mice with one dose of 120 mg/kg N-ethyl-N-nitrosourea (ENU), a model genotoxic carcinogen, and vehicle control. The gene expression profiles were assessed in the mouse livers in wild-type a...
ORGANISM(S): Mus musculus 
2012-03-06 | E-GEOD-36307 | biostudies-arrayexpress
TranscriptomicsPla2g12b and Hpn are Genes Identified by Mouse ENU Mutagenesis that affect HDL cholesterol
Despite considerable progress understanding genes that affect the HDL particle, its function, and cholesterol content, genes identified to date explain only a small percentage of the genetic variation. We used N-ethyl-N-nitrosourea mutagenesis in mice to discover novel genes that affect HDL choleste...
ORGANISM(S): Mus musculus 
2012-06-30 | E-GEOD-37902 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of Caenorhabditis elegans exposed to three hydrophilic genotoxicants in water in duplicate
In this study, we exposed Caenorhabditis elegans wild types N2 to two concentrations of the model genotoxicants formaldehyde (HCHO), N-ethyl-N-nitrosourea (ENU), and methyl methanesulfonate (MMS).We performed a concentration-response test to determine the non-toxic concentration range for studying t...
ORGANISM(S): Caenorhabditis elegans 
2021-04-23 | E-MTAB-10264 | biostudies-arrayexpress
TranscriptomicsGene expression in liver of wild-type and Dicer1-KO mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea
To explore the possible changes of gene expression induced by a carcinogen, we treated wild-type and Dicer1-KO mice with one dose of 120 mg/kg N-ethyl-N-nitrosourea (ENU), a model genotoxic carcinogen, and vehicle control. The gene expression profiles were assessed in the mouse livers in wild-type a...
ORGANISM(S): Mus musculus 
2012-03-06 | GSE36307 | GEO
TranscriptomicsIdentification and validation of novel ERBB2 (HER2, NEU) targets including genes
V-erb-b2 erythroblastic leukemia viral oncogene homolog 2 (ERBB2; synonyms HER2, NEU) encodes a transmembrane glycoprotein with tyrosine kinase-specific activity that acts as a major switch in different signal-transduction processes. ERBB2 amplification and overexpression have been found in a number...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-16445 | biostudies-arrayexpress
UnknownChromoanasynthetic Genomic Rearrangement Identified in a N-Ethyl-N-Nitrosourea (ENU) Mutagenesis Screen in Caenorhabditis elegans.
Not available
S-EPMC4751554 | biostudies-literature
OtherGenomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea
Dysregulated expression of microRNA (miRNA) has been extensively detected in human cancer tissues and has shown promise in defining tumor status. It, however, is little known whether and when expression of miRNAs can be changed in normal tissues after carcinogen exposure. To explore possible time-co...
ORGANISM(S): Mus musculus 
2010-11-04 | GSE20248 | GEO
UnknownAdopting duplex sequencing technology for genetic toxicity testing: A proof-of-concept mutagenesis experiment with N-ethyl-N-nitrosourea (ENU)-exposed rats.
Not available
S-EPMC10539650 | biostudies-literature
UnknownComparison of imatinib mesylate, dasatinib (BMS-354825), and nilotinib (AMN107) in an N-ethyl-N-nitrosourea (ENU)-based mutagenesis screen: high efficacy of drug combinations.
Not available
S-EPMC1895563 | biostudies-literature
TranscriptomicsCharacterization of chemically induced malignant peripheral nerve sheath tumors (MPNSTs) in the rat by expression profiling
Identification of differentially expressed genes in ENU induced MPNSTs and normal tissue from rat Nervus trigeminus by expression profiling Gene expression of total RNA isolated from pooled, untreated trigeminal nerves from 85 days old rats compared to unpooled total MPNST tumor RNA from BDIV, BD...
ORGANISM(S): Rattus norvegicus 
2012-03-28 | E-GEOD-36144 | biostudies-arrayexpress
Sort   by:  
 Page size