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ProteomicsSolid-phase extraction of N-linked glycans and glycosite-containing peptides (NGAG) for comprehensive characterization of glycoproteins
A novel chemoenzymatic method termed solid phase extraction of N-linked Glycans And Glycosite-containing peptides (NGAG) for the simultaneous analysis of N-glycans, glycosite-containing peptides, and intact N-glycopeptides with site-specific glycosylation information.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080840 | MassIVE
GenomicsN-linked glycosylation is essential for anti-tumor activities of KIAA1324 in gastric cancer
N-linked glycosylation is essential for anti-tumor activities of KIAA1324 in gastric cancer
PRJNA1001364 | ENA
ProteomicsTrans-Golgi protein TVP23B regulates host-microbe interactions via Paneth cell homeostasis and Goblet cell glycosylation
A key feature in intestinal immunity is the dynamic intestinal barrier, which separates the host from resident and pathogenic microbiota through a mucus gel impregnated with antimicrobial peptides. The mechanisms underlying the maintenance and function of this intestinal barrier are not completely ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-12-12 | MSV000090883 | MassIVE
ProteomicsProtein N-glycosylation of SARS-CoV-2 infection
SARS-CoV-2 extensively N-glycosylates its spike proteins, which are essential for host cell invasion, target of vaccines, and immunotherapy. These N-glycans are predicted to help mediate spike binding to the host receptor. We investigated the essentiality of the host N-glycosylation pathway and viru...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 
2022-02-04 | PXD026431 | Pride
N-glycosylation inhibition Sars-cov-2 Viral infection Coronavirus Covid-19 Drug repurposing 
ProteomicsSystematic Quantification of Protein O-GlcNAcylation Reveals Common and Cell-Type-Specific Responses to N-Glycosylation Inhibition in Human Cells
In this work, we systematically and site-specifically analyzed protein O-GlcNAcylation under the N-glycosylation inhibition through the integration of metabolic labeling, bio-orthogonal chemistry, and multiplexed proteomics. The experiments were performed in three types of human cells, i.e., HEK293T...
ORGANISM(S): Homo sapiens (Human) 
2026-06-02 | PXD073249 | Pride
Glycoproteomics Protein o-glcnacylation 
TranscriptomicsN-linked glycosylation is essential for anti-tumor activities of KIAA1324 in gastric cancer
KIAA1324 is a transmembrane protein largely reported as a tumor suppressor and favorable prognosis marker in various cancers, including gastric cancer. In this study, we report the role of N-linked glycosylation in KIAA1324 as a functional post-translational modification (PTM). Loss of N-linked glyc...
ORGANISM(S): Homo sapiens 
2023-08-07 | GSE239904 | GEO
ProteomicsNascent glycoproteome reveal the suppressed expression of glycosylated LAMP2 in response to N-linked glycosylation inhibition
(1) Analysis of newly synthesized proteins under glycosylation inhibition (2) Analysis of newly synthesized glycoproteins during NGI-1 treatment
ORGANISM(S): Homo Sapiens 
PXD028212 |
ProteomicsTargeting conserved N-glycosylation eradicates SARS-CoV-2 variants infection
To assess the binding ability of glycosylated or deglycosylated spike with ACE2, we performed flow cytometry, ELISA, and BioLayer Interferometry methods. Viral entry ability was determined by luciferase intensity, immunoblotting, and immunofluorescence assay. A genome-wide association study (GWAS) w...
ORGANISM(S): Human 
2021-06-23 | MSV000087686 | MassIVE
ProteomicsDysregulation of N-glycosylation by RPN1 knockout in spermatocytes induces male infertility via impaired mitochondrial function in mice
N-glycosylation protein modifications play a crucial regulatory role in numerous biological processes, although their contribution to male reproduction in mammals remains largely undefined. Here, we found that Ribophorin I (RPN1), a subunit of oligosaccharyltransferase complex, is indispensable for ...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD051379 | Pride
Rpn1  n-glycosylation  meiosis  spermatogenesis  fertility 
UnknownSelective inhibition of N-linked glycosylation impairs receptor tyrosine kinase processing.
Not available
S-EPMC6602306 | biostudies-literature
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