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ProteomicsEvaluation of NHS-Acetate and DEPC labelling for determination of solvent accessible amino acid residues in protein complexes
The structural analysis of proteins and protein complexes is key for understanding their function and regulation. In order to gain structural information, we examined protein surface labelling using NHS-Acetate and DEPC following an MS-based workflow. Using two model proteins we characterise the obt...
ORGANISM(S): Oryctolagus cuniculus cuniculus Saccharomyces cerevisiae (Baker's yeast) 
2020-05-05 | PXD015940 | Pride
Diethylpyrocarbonate N-hydroxysuccinimidyl acetate Mass spectrometry Neutral loss Chemical labelling Solvent accessible surface area Labelling percentage 
ProteomicsAcylated peptide enrichment utilizing lysine deacylases for lysine acylomics
Reversible acylation of lysine ε-amino groups, e.g., acetylation, succinylation, maronylation, and myristoylation, is involved in basic physiological processes such as metabolism, cell signaling and aging. In this study, we developed a novel enrichment method for acylated peptides without the use of...
ORGANISM(S): Homo Sapiens (human) 
2021-06-03 | PXD025845 | JPOST Repository
TranscriptomicsTranscription profiling of yeast wild type, set1delta and swd3delta SK1 diploid cells in response to sporulation conditions, in order to determine the influence of histone methylation on the meiotic transcriptome
We analysed the global gene expression profile of wild-type, set1delta and swd3delta Saccharomyces cerevisiae SK1 diploid cells in response to sporulation conditions, in order to determine the influence of histone methylation on the meiotic transcriptome.
ORGANISM(S): Saccharomyces cerevisiae 
2004-05-05 | E-MEXP-41 | biostudies-arrayexpress
TranscriptomicsTranscriptomic regulation and methylation of the Lysine4 of Histone H3 during meiosis
This SuperSeries is composed of the following subset Series: GSE10836: Meiotic time course of Histone H3 occupancy GSE10837: Meiotic time course of the trimethylation of the Lysine 4 of Histone H3 (H3K4me3) in a mutant Spo11F GSE10838: Meiotic time course of Histone H3 occupancy in a mutant Spo11F G...
ORGANISM(S): Saccharomyces cerevisiae 
2008-10-31 | E-GEOD-11004 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of p56lck-deficient regulatory and memory T cells
Signaling through the T cell antigen receptor is essential for the formation of regulatory T (Treg) cells in the thymus and for their involvement in antigen-directed suppression of immune responses. Using a conditional null allele of the gene encoding p56Lck we show here that T cell antigen recepto...
ORGANISM(S): Mus musculus 
2010-05-22 | E-GEOD-13645 | biostudies-arrayexpress
TranscriptomicsTranscriptomic regulation during meiosis (Spo11Y135F mutant)
We studied the meiotic regulation of transcription in the mutant Spo11Y135F (deficient for the formation of meiotic double-strand breaks), by comparing the mRNA level at time t=1h to t=8h after meiosis induction, to the mRNA level at time t=0h. Keywords: yeast meiotic time course, transcriptome For ...
ORGANISM(S): Saccharomyces cerevisiae 
2008-10-31 | E-GEOD-10947 | biostudies-arrayexpress
TranscriptomicsTranscriptomic regulation during meiosis (Clb5Delta-Clb6Delta mutant)
We studied the meiotic regulation of transcription in the mutant Clb5Delta-Clb6Delta (deficient for the meiotic replication), by comparing the mRNA level at time t=1h to t=8h after meiosis induction, to the mRNA level at time t=0h. Keywords: yeast meiotic time course, transcriptome For each time poi...
ORGANISM(S): Saccharomyces cerevisiae 
2008-10-31 | E-GEOD-10948 | biostudies-arrayexpress
TranscriptomicsTranscriptomic regulation during meiosis
We studied the meiotic regulation of transcription, by comparing the mRNA level at time t=1h to t=8h after meiosis induction, to the mRNA level at time t=0h. Keywords: yeast meiotic time course, transcriptome For each time point, we measured the level of mRNA extracted at the time point to a mRNA me...
ORGANISM(S): Saccharomyces cerevisiae 
2008-10-31 | E-GEOD-10944 | biostudies-arrayexpress
ProteomicsHb Oxidation in stored RBCs and Vesicles
We used a state of the art proteomics workflow, based upon nano-UPLC-MS\MS and advanced database searching to identify oxidative modifications to functional residues of hemoglobin subunit beta . Progressive accumulation of oxidized residues in stored erythrocytes and selective removal in vesicles wa...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-04 | MSV000080222 | MassIVE
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