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TranscriptomicsGlobal gene profiling comparison between hydrogen sulfide- and N-methyl-D-aspartate-induced neuronal deaths
Hydrogen sulfide (H2S), present in abundance in the mammalian brain, has recently been demonstrated to induce a dose- and time-dependent apoptotic-necrotic continuum in murine primary cortical neurons, which was successfully attenuated upon application of N-methyl-D-aspartate (NMDA) receptor antagon...
ORGANISM(S): Mus musculus 
2013-01-23 | E-GEOD-16035 | biostudies-arrayexpress
ProteomicsProteome of proline betaine-grown Eubacterium limosum ATCC 8486
Proline betaine, and to a much lesser extent, N-methyl L-proline, are found in citrus fruits and often present in the human metabolome. However, most of the N-methyl L-proline found in an animal model metabolome is produced by the microbiota, yet organisms and enzymes capable of producing N-methyl p...
ORGANISM(S): Eubacterium limosum Bacteria 
2019-07-25 | PXD013962 | Pride
Human gut isolate Acetogenic bacteria Proline betaine N-methyl proline 
TranscriptomicsDynamic mRNA gene expression during a nutritional upshift from proline to glutamine
Dynamic mRNA gene expression from the wildtype YSBN6 during a nutritional upshift from proline to glutamine. Glutamine was added to yeast cells growing exponentially on proline as the sole nitrogen source. A sample was taken at steady-state 10 minutes before the shift, and then 3, 7, 10, 14, 24, 56 ...
ORGANISM(S): Saccharomyces cerevisiae 
2015-04-07 | E-GEOD-54844 | biostudies-arrayexpress
TranscriptomicsDynamic mRNA gene expression during a nutritional downshift from glutamine to proline
Dynamic mRNA gene expression from the wildtype YSBN6 during a nutritional downshift from glutamine to proline. Glutamine and proline were initially together in the media, with cells consuming exlusively glutamine (proline utilization inhibited due to nitrogen catabolite repression). The concentratio...
ORGANISM(S): Saccharomyces cerevisiae 
2015-04-07 | E-GEOD-54850 | biostudies-arrayexpress
UnknownN-Amino-l-Proline Methyl Ester from an Australian Fish Gut-Derived Fungus: Challenging the Distinction between Natural Product and Artifact.
Not available
S-EPMC7999761 | biostudies-literature
MetabolomicsMolecular Docking and Dynamic Study of Ethanol Extract of Citrus sinensis as Keap-1 and NMDA inhibitor in Brain Injury

Traumatic brain injury is a significant cause of mortality in young adults and disability in all age groups. Secondary injury involving various processes such as oxidative stress, which induced neuronal apoptosis, ensued afterward. This study aimed to analyze the active compounds of Citrus sinens...

2023-01-02 | MTBLS5785 | MetaboLights
TranscriptomicsNitrogen source-dependent capsule induction in human pathogenic Cryptococcus species.
Cryptococcus neoformans causes meningoencephalitis and is an increasing human health threat. C. neoformans is neurotropic, and persists in the cerebrospinal fluid (CSF) of the mammalian host during infection. In order to survive in the host, pathogenic fungi must procure nutrients such as carbon a...
ORGANISM(S): Cryptococcus neoformans 
2013-09-25 | E-GEOD-46829 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HT29 colorectal adenocarcinoma cell line treated with apratoxin A vs. controls to determine the mode of action of apratoxin A
Total RNA was extracted from apratoxin A or vehicle treated HT29 cells using the RNeasy Mini Kit (Qiagen). Probe values from CEL files were condensed to probe sets using Rosetta Resolver software. Resolver ANOVA analysis was then performed between groups. Experiment Overall Design: 2 doses were co...
ORGANISM(S): Homo sapiens 
2007-10-27 | E-GEOD-2742 | biostudies-arrayexpress
MetabolomicsMetabolic adaptation of diatoms to hypersalinity

Microalgae are important primary producers and form the basis for the marine food web. As global climate changes, so do salinity levels that algae are exposed to. A metabolic response of algal cells partly alleviates the resulting osmotic stress. Some metabolites involved in the response are well...

2023-09-04 | MTBLS3177 | MetaboLights
TranscriptomicsDietary enrichments cause alterations in metabolome, transcriptome and improve freeze-tolerance in larvae of the fruit fly (Drosophila melanogaster).
In this experiment, Drosophila melanogaster larvae were fed with Proline and Arginine compounds and showed a better tolerance to freezing compared to control larvae. Using a microarray approach, we investigated the alteration of transcriptome profiles in larvae fed with Proline or Arginine versus co...
ORGANISM(S): Drosophila melanogaster 
2019-01-01 | E-MTAB-3911 | biostudies-arrayexpress
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