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TranscriptomicsIn TCR-stimulated T-cells, N-ras regulates specific genes and signal transduction pathways
It has been recently shown that N-ras plays a preferential role in immune cell development and function; specifically: N-ras, but not H-ras or K-ras, could be activated at and signal from the Golgi membrane of immune cells following a low level TCR stimulus. The goal of our studies was to test the...
ORGANISM(S): Mus musculus 
2013-04-04 | E-GEOD-45739 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of ouse fibroblasts lacking H-Ras and/or NRas with those of matching, WT controls - reveals serum-dependent transcriptional networks identify distinct functional roles for H-ras and N-ras
Serum-dependent transcriptional networks identify distinct functional roles for H-ras and N-ras during initial stages of the cell cycle; Using oligonucleotide microarrays, we compared gene expression transcriptional profiles corresponding to the initial cell cycle stages of mouse fibroblasts lacking...
ORGANISM(S): Mus musculus 
2009-09-15 | E-GEOD-14829 | biostudies-arrayexpress
TranscriptomicsIsolation of subtype-specific N-Ras responsive genes in basal-like breast cancer cells
To identify the the N-Ras-controlled genes in basal-like cells, we used shRNA to repress N-RAS in basal-like SUM102PT, SUM149PT and claudin-low SUM159PT cells. We seek the genes regulated only in basal-like, but not in claudin-low cells, to isolate the genes controlled by N-Ras in a breast cancer su...
ORGANISM(S): Homo sapiens 
2015-06-06 | E-GEOD-61768 | biostudies-arrayexpress
GenomicsNeuroblastoma RAS viral oncogene homolog (N-RAS) deficiency aggravates liver injury and fibrosis
Neuroblastoma RAS viral oncogene homolog (N-RAS) deficiency aggravates liver injury and fibrosis
PRJNA993123 | ENA
ProteomicsABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth
A subset of Ras proteins, including N-Ras, depend on a palmitoylation/depalmitoylation cycle to regulate their subcellular trafficking and oncogenicity. General lipase inhibitors such as Palmostatin M block N-Ras depalmitoylation, but lack specificity and target several enzymes displaying depalmitoy...
ORGANISM(S): Homo sapiens (Human) 
2021-04-28 | PXD023932 | Pride
N-ras Abhd17 Palmitoylation Human acute myeloid leukemia 
TranscriptomicsReversible mRNA and miRNA expression patterns in the transcriptome of Rasless fibroblasts
Analysis of the transcriptional profiles of mRNA and microRNA in Rasless fibroblasts. 4-Hydroxy-tamoxifen (4-OHT) treatment triggers removal of K-Ras expression in [H-Ras-/-;N-Ras-/-;K-Raslox/lox;RERTert/ert] mouse fibroblasts (named K-Raslox) generating M-bM-^@M-^\RaslessM-bM-^@M-^] MEFs which are ...
ORGANISM(S): Mus musculus 
2013-11-27 | E-GEOD-45222 | biostudies-arrayexpress
TranscriptomicsSerum-dependent transcriptional networks identify distinct functional roles for H-ras and N-ras
Serum-dependent transcriptional networks identify distinct functional roles for H-ras and N-ras during initial stages of the cell cycle Using oligonucleotide microarrays, we compared gene expression transcriptional profiles corresponding to the initial cell cycle stages of mouse fibroblasts lacking ...
ORGANISM(S): Mus musculus 
2009-09-01 | GSE14829 | GEO
TranscriptomicsNeuroblastoma RAS viral oncogene homolog (N-RAS) deficiency aggravates liver injury and fibrosis
To gain insight into the differential signaling pathways triggered in N-RAS-/- versus N-RAS+/+ mice during liver injury and fibrosis, we performed microarray analyses of livers 28 days after CCl4 treatment and BDL surgery, respectively. Our findings suggested that increased cell proliferation and ma...
ORGANISM(S): Mus musculus 
2023-07-15 | GSE236915 | GEO
TranscriptomicsIn TCR-stimulated T-cells, N-ras regulates specific genes and signal transduction pathways
It has been recently shown that N-ras plays a preferential role in immune cell development and function; specifically: N-ras, but not H-ras or K-ras, could be activated at and signal from the Golgi membrane of immune cells following a low level TCR stimulus. The goal of our studies was to test the h...
ORGANISM(S): Mus musculus 
2013-04-04 | GSE45739 | GEO
TranscriptomicsWild type N-ras displays anti-malignant properties, in part by downregulating decorin
Previously, we have demonstrated that wild type N-ras (wt N-ras) harbors an anti-malignant effect against mutated Ras and in tumors without Ras mutations. To investigate the molecular bases of this anti-malignant activity, we have studied the potency of this anti-malignant effect in a model system a...
ORGANISM(S): Mus musculus 
2011-04-19 | GSE28678 | GEO
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