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ProteomicsN4BP1 is a unique, dimerization-dependent linear ubiquitin reader that regulates TNFR1 signalling through linear ubiquitin binding and Caspase-8-dependent processing
Signalling through TNFR1 modulates proinflammatory gene transcription and programmed cell death, and its impairment causes autoimmune diseases and cancer. NEDD4 binding protein 1 (N4BP1) was recently identified as a critical suppressor of proinflammatory cytokine production1, whose mode of action re...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD024355 | Pride
Caspase 8 Proteolytic processing N4bp1 
GenomicsN4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization
N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization
PRJNA698568 | ENA
ProteomicsIntegration of Innate Immune Signaling by 2 Caspase-8-Mediated Cleavage of N4BP1
Integration of Innate Immune Signaling by 2 Caspase-8-Mediated Cleavage of N4BP1
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000086111 | MassIVE
UnknownEnteroviral 3C protease cleaves N4BP1 to impair the host inflammatory response.
Not available
S-EPMC11784292 | biostudies-literature
UnknownThe endoribonuclease N4BP1 prevents psoriasis by controlling both keratinocytes proliferation and neutrophil infiltration.
Not available
S-EPMC8121926 | biostudies-literature
UnknownN4BP1 mediates RAM domain-dependent notch signaling turnover during neocortical development.
Not available
S-EPMC10646556 | biostudies-literature
GenomicsRegulation of IkB kinase family crosstalk by an N4BP1-caspase-8 axis [scRNA-seq]
Regulation of IkB kinase family crosstalk by an N4BP1-caspase-8 axis [scRNA-seq]
PRJNA906452 | ENA
GenomicsRegulation of IkB kinase family crosstalk by an N4BP1-caspase-8 axis [ChIP-seq]
Regulation of IkB kinase family crosstalk by an N4BP1-caspase-8 axis [ChIP-seq]
PRJNA906449 | ENA
UnknownN4BP1 functions as a dimerization-dependent linear ubiquitin reader which regulates TNF signalling.
Not available
S-EPMC11032371 | biostudies-literature
GenomicsRegulation of IkB kinase family crosstalk by an N4BP1-caspase-8 axis [RNA-seq NGS3611]
Regulation of IkB kinase family crosstalk by an N4BP1-caspase-8 axis [RNA-seq NGS3611]
PRJNA906450 | ENA
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