Sort   by:  
 Page size 
ProteomicsGlobal Lysine Acetylome Analysis of LPS-Stimulated HepG2 Cells Identifies Hyperacetylation of PKM2 as a Metabolic Reg-ulator in Sepsis
Sepsis-induced liver dysfunction is a frequent event and is strongly associated with mortality. Establishing a causative link between protein post-translational modification (PTM) and diseases is challenging. We studied the relationship among the lysine acetylation (Kac), the sirtuin (SIRTs), and th...
ORGANISM(S): Homo sapiens (Human) 
2024-01-30 | PXD027496 | Pride
Sepsis-induced liver dysfunction  hyperacetylation  sirt  lysine acetylation  pyruvate kinase m2 
ProteomicsIdentification of the novel progression factors in renal cell carcinoma through global proteomics
Renal cell carcinoma (RCC) is among the top 8 most diagnosed cancer in United States, which 79,000 patients newly were diagnosed and 13,920 deaths [1]. The clear-cell RCC (ccRCC) is the most common histopathological subtype representing approximately 85~90% in all diagnosed case [2]. In renal cancer...
ORGANISM(S): Homo sapiens (Human) 
2024-01-30 | PXD039207 | Pride
Human Renal carcinoma cell 
ProteomicsComparative quantitative proteomics in renal cell carcinoma to identify the novel progression factors
Over 90% of kidney malignancies are renal cell carcinomas (RCC), which are tumors arising from the renal epithelium. Clear cell RCC (ccRCC) is the most frequent histological subtype and the cause of the majority of kidney cancer-related fatalities. Because of its low 5-year survival rate, poor progn...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD039204 | Pride
: clear cell renal carcinoma  metastasis  comparative proteomics  prognostic marker  serpine a3 
ProteomicsCRPC biomarker via proteomic analysis
Identifying biological change from hormone-naive prostate cancer to CRPC is a major clinical challenge for developing therapeutic agents. Although the pathways that lead to CRPC are not fully understood, recent evidence demonstrates that androgen signaling is often maintained through varied mechanis...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD023592 | Pride
: comparative proteomics  prostate cancer  foxa1  androgen deprivation therapy  crpc 
ProteomicsCharacterization of hyperglycemia due to sub-chronic administration of red ginseng extract via comparative global proteomic analysis
Ginseng (Panax ginseng Meyer) is commonly used as an herbal remedy worldwide. Few studies have explored the possible physiological changes in the liver although patients often self-medicate with ginseng preparations, which may lead to exceeding the recommended dose for long-term administration. Here...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-10 | PXD023731 | Pride
Korean red ginseng  proteomics  cystathionin beta-synthase  cystathionine gamma- lyase  hydrogen sulfide 
ProteomicsIntegrative multi-omics analysis in sepsis-associated liver dysfunction
we conducted integrative multiple levels of omics data including transcriptome, phosphoproteome, proteome and metabolome in different time-course of sepsis-associated liver dysfunction (SALD). This is the first trial to suggest the statistical pathway of integrative multi-omics data in sepsis. Given...
ORGANISM(S): Mus musculus (Mouse) 
2023-06-21 | PXD025800 | Pride
Sepsis Liver dysfunction Multiomics Integrative omics 
Sort   by:  
 Page size