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ProteomicsDifferential N-terminal COFRADIc analyses of Ogden fibroblasts
The X-linked lethal Ogden syndrome was the first reported human genetic disorder associated with a mutation in an N-terminal acetyltransferase gene. The affected males harbour a Ser37Pro mutation in the gene encoding hNaa10, the catalytic subunit of NatA, themajor human NAT. In order to understand t...
ORGANISM(S): Homo sapiens (Human) 
2016-04-12 | PXD001282 | Pride
Human Naa10 s37p mutation N-terminal acetylation Differential cofradic Fibroblasts Lc-ms/ms 
TranscriptomicsProteomic and genomic characterization of a yeast model for Ogden syndrome [RNA-seq and Ribo-seq]
Naa10 is a Nα-terminal acetyltransferase that, in a complex with its auxiliary subunit Naa15, co-translationally acetylates the α-amino group of newly synthetized proteins as they emerge from the ribosome. Roughly 40-50% of the human proteome is acetylated by Naa10, rendering this an enzyme with one...
ORGANISM(S): Saccharomyces cerevisiae 
2016-09-07 | GSE86466 | GEO
TranscriptomicsProteomic and genomic characterization of a yeast model for Ogden syndrome [microarray]
Gene expression microarrays accompanying "Proteomic and genomic characterization of a yeast model for Ogden syndrome" by Doerfel et al 2016 in press at Yeast. Naa10 is a Na-terminal acetyltransferase that, in a complex with its auxiliary subunit Naa15, co-translationally acetylates the a-amino group...
ORGANISM(S): Saccharomyces cerevisiae 
2016-09-03 | GSE86358 | GEO
UnknownA Saccharomyces cerevisiae model reveals in vivo functional impairment of the Ogden syndrome N-terminal acetyltransferase NAA10 Ser37Pro mutant.
Not available
S-EPMC4125735 | biostudies-literature
ProteomicsProteomic and genomic characterization of a yeast model for Ogden Syndrome
Naa10 is a N-terminal acetyltransferase that, in a complex with its auxiliary subunit Naa15, co-translationally acetylates the -amino group of newly synthetized proteins as they emerge from the ribosome. Roughly 40-50% of the human proteome is acetylated by Naa10, rendering this an enzyme with one o...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2016-09-28 | PXD004923 | Pride
Ogden syndrome 
UnknownProteomic and genomic characterization of a yeast model for Ogden syndrome.
Not available
S-EPMC5248646 | biostudies-literature
UnknownBiochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects.
Not available
S-EPMC4355026 | biostudies-literature
ProteomicsA Saccharomyces Cerevisiae model reveals in vivo functional impairment of the ogden syndrome n-terminal acetyltransferase Naa10-S37p mutant
Abstract: N-terminal acetylation (Nt-acetylation) occurs on the majority of eukaryotic proteins and is catalysed by N-terminal acetyltransferases (NATs). Nt- acetylation is increasingly recognized as a vital modification with functional implications ranging from protein degradation to protein locali...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2014-01-29 | PXD000316 | Pride
Lc-msms Yeast N-terminal cofradic 
GenomicsSaccharomyces cerevisiae
Proteomic and genomic characterization of a yeast model for Ogden syndrome [RNA-seq and Ribo-seq]
PRJNA342004 | ENA
GenomicsSaccharomyces cerevisiae
Proteomic and genomic characterization of a yeast model for Ogden syndrome [microarray]
PRJNA341685 | ENA
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