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TranscriptomicsDetermination of the FarR regulon
Whole genome DNA microarray of Neisseria meningitidis serogroup B strain MC58 and the isogenic mutant strain deficient of the transcriptional regulator FarR, MC58 M-bM-^HM-^FfarR. Wild type MC58 and the farR deficient mutant strain MC58 M-bM-^HM-^FfarR were grown to mid-exponential growth phase in t...
ORGANISM(S): Neisseria meningitidis 
2011-02-11 | E-GEOD-20643 | biostudies-arrayexpress
UnknownTreatment- and population-specific genetic risk factors for anti-drug antibodies against interferon-beta: a GWAS.
Not available
S-EPMC7641861 | biostudies-literature
ProteomicsA Circulating Antibody Panel for Pre-transplant Prediction of FSGS Recurrence after Kidney Transplantation
Recurrence of focal segmental glomerulosclerosis (rFSGS) after kidney transplantation is a cause of early and accelerated graft loss. Immuneadsorption can alleviate renal dysfunction and suggests that circulating antibodies (Ab) are likely implicated in disease pathogenesis. To evaluate pathogenic A...
ORGANISM(S): Homo sapiens 
2014-11-04 | E-GEOD-57099 | biostudies-arrayexpress
TranscriptomicsGAP aflR- vs WT timecourse
The carcinogen aflatoxin is synthesized by a cluster of genes that are regulated by the transcriptional factor, AflR. Most, but not all of these genes, have a consensus binding site for AflR in their 5’ untranslated region. Because aflR resides within the biosynthetic cluster, is has been sugges...
ORGANISM(S): Aspergillus parasiticus 
2010-06-10 | E-GEOD-2709 | biostudies-arrayexpress
TranscriptomicsEpidermal differentiation: basal vs. suprabasal keratinocytes
In epidermal differentiation basal keratinocytes detach from the basement membrane, stop proliferating, and express a new set of structural proteins and enzymes, which results in an impermeable protein/lipid barrier that protects us. To define the transcriptional changes essential for this process, ...
ORGANISM(S): Homo sapiens 
2010-12-15 | E-GEOD-26059 | biostudies-arrayexpress
TranscriptomicsLong-term pioglitazone improves learning and attenuates pathological markers in a mouse model of AD
Thiazolidinediones (TZDs) are agonists at peroxisome proliferator-activated gamma-type (PPAR-y) receptors and are used clinically for the treatment of type 2 diabetes where they have been shown to reestablish insulin sensitivity, improve lipids profile, and reduce inflammation. Recent work also sugg...
ORGANISM(S): Mus musculus 
2012-04-12 | E-GEOD-32536 | biostudies-arrayexpress
TranscriptomicsDeep Sleep and Parietal Cortex Gene Expression Changes are Related to Cognitive Deficits with Age
Background: Age-related cognitive deficits negatively affect quality of life and can presage serious neurodegenerative disorders. Despite sleep disruption’s well-recognized negative influence on cognition, and its prevalence with age, surprisingly few studies have tested sleep’s relationship to cogn...
ORGANISM(S): Rattus norvegicus 
2011-04-21 | E-GEOD-24515 | biostudies-arrayexpress
TranscriptomicsPorphyromonas gingivalis W50 Heme-excess vs Heme-limitation
Transcription profiling of P. gingivalis W50 grown in continuous culture under conditions of heme-excess and heme-limitation. Reference design (using Cy5 labelled genomic DNA as the reference) to compare two conditions: heme-excess vs heme-limitation. Three samples for each condition, independently...
ORGANISM(S): Porphyromonas gingivalis 
2010-05-16 | E-GEOD-13375 | biostudies-arrayexpress
TranscriptomicsThe Influence of Sleep Deprivation on Hippocampal CA1 Gene Expression: Relation to Stress and Aging
Sleep deprivation (SD) in young adults is associated with metabolic, stress and cognitive responses that are also characteristic of brain aging. Given that sleep architecture changes with age, including increased fragmentation and decreased slow wave activity, it seems reasonable to investigate pote...
ORGANISM(S): Rattus norvegicus 
2012-07-16 | E-GEOD-34424 | biostudies-arrayexpress
TranscriptomicsAlterations in the transcriptome and antibiotic susceptibility of Staphylococcus aureus grown in the presence of diclofenac
Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) which has been shown to increase the susceptibility of various bacteria to antimicrobials and demonstrated to have broad antimicrobial activity. This study describes transcriptome alterations in S. aureus strain COL grown with diclofenac ...
ORGANISM(S): Staphylococcus aureus subsp. aureus COL 
2011-07-18 | E-GEOD-30724 | biostudies-arrayexpress
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