The Influence of Sleep Deprivation on Hippocampal CA1 Gene Expression: Relation to Stress and Aging

ABSTRACT: Sleep deprivation (SD) in young adults is associated with metabolic, stress and cognitive responses that are also characteristic of brain aging. Given that sleep architecture changes with age, including increased fragmentation and decreased slow wave activity, it seems reasonable to investigate potential molecular relationships between SD and aging in brain tissue. Here, we tested the hypothesis that young rats exposed to 24 or 72 hour SD would respond with stress and aging-like shifts in brain hippocampal CA1 gene expression. SD animals showed blood corticosterone and weight changes consistent with a stress response. Microarray results, validated by Western blot and comparison to prior SD studies, pointed to disruptions in neurotransmission, sleep pressure signaling, and macromolecular sy

ORGANISM(S): Rattus norvegicus

SUBMITTER: Eric Blalock 

PROVIDER: E-GEOD-34424 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress