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ProteomicsStructure of the Homodimeric Androgen Receptor Ligand-Binding Domain
The androgen receptor (AR) plays a crucial role in normal physiology, development and metabolism as well as in the etiology and treatment of diverse pathologies such as androgen insensitivity syndromes (AIS), male infertility, and prostate cancer (PCa). Here, we show that dimerization of AR ligand-b...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD005575 | Pride
Ar Cross-linking 
ProteomicsThe molecular bases of spinal muscular atrophy
Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by the absence of a functional Survival of Motor Neuron 1 gene (SMN1). The nearly identical paralog, SMN2, cannot compensate for the loss of SMN1 because exon 7 is aberrantly skipped from most SMN2 transcripts, a process mediated by...
ORGANISM(S): Homo sapiens (Human) 
2024-05-23 | PXD033055 | Pride
Biological sciences/molecular biology/rna metabolism/alternative splicing biological sciences/structural biology/x-ray crystallography health sciences/diseases/neurological disorders/motor neuron disease 
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