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TranscriptomicsTranscription profiling of human pilocytic astrocytoma to develop molecular signatures
Pilocytic astrocytomas (PAs) are the most common glioma in children. While many PAs; are slow growing or clinically indolent, others exhibit more aggressive features with tumor; recurrence and death. In order to identify genetic signatures that might predict PA clinical; behavior, we performed gene ...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-5675 | biostudies-arrayexpress
UnknownTranslational bioinformatics in mental health: open access data sources and computational biomarker discovery.
Not available
S-EPMC6585382 | biostudies-literature
TranscriptomicsTranscription profiling of mouse neocortical and cerebellar astrocytes
Affymetrix Mouse Genome 430 2.0 GeneChip microarrays were used to analyze murine neocortical and cerbellar astrocytes generated from postnatal (PN) day 1 wild-type (ICR) pups. Experiment Overall Design: Three samples each of murine neocortical and cerebellar astrocytes were analyzed.
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5582 | biostudies-arrayexpress
TranscriptomicsRARA haploinsufficiency modestly influences the phenotype of APL.
RARA haploinsufficiency is an invariable consequence of t(15;17) reciprocal translocations in acute promyelocytic leukemia (APL). Furthermore, retinoids and RARA activity have been implicated in hematopoietic self-renewal, lineage commitment and neutrophil maturation. We and others therefore predict...
ORGANISM(S): Mus musculus 
2010-07-29 | E-GEOD-23291 | biostudies-arrayexpress
TranscriptomicsmCG-PML-RARA alters multipotent hematopoiesis.
Acute promyelocytic leukemia (APL) is associated with PML-RARA expression and late myeloid maturation arrest. The myeloid restriction of PML-RARA dependent leukemia has been recapitulated in multiple mouse models of APL, including PML-RARA expressed from the Ctsg locus (mCG-PR). However, we report h...
ORGANISM(S): Mus musculus 
2010-10-21 | E-GEOD-24728 | biostudies-arrayexpress
TranscriptomicsExpression and function of PML-RARA in the multipotent hematopoietic progenitor cells of Ctsg-PML-RARA mice
Because PML-RARA-positive acute promyelocytic leukemia (APL) is a morphologically differentiated leukemia, much speculation has been made about whether its leukemic cell of origin might be committed myeloid precursor (e.g., a promyelocyte) vs. a hematopoietic stem/progenitor cell (HSPC). We original...
ORGANISM(S): Mus musculus 
2012-08-13 | E-GEOD-40022 | biostudies-arrayexpress
GenomicsAcquired Copy Number Alterations in Adult Acute Myeloid Leukemia Genomes

We performed genome-wide copy number analysis with paired normal and tumor DNA obtained from 86 adult patients with de novo AML using the Affymetrix Genome-Wide Human SNP array 6.0 containing 1.85 million features. Acquired copy number alterations (CNA) were confirmed using an independent, hig...

phs000201.v1.p1 | EGA
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