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GenomicsH4K12ac is regulated by estrogen receptor-alpha and is associated with BRD4 function and inducible transcription
Hormone-dependent gene expression requires dynamic and coordinated epigenetic changes. Estrogen receptor-positive (ER+) breast cancer is particularly dependent upon extensive chromatin remodeling and changes in histone modifications for the induction of hormone-responsive gene expression. Our previo...
ORGANISM(S): Homo sapiens 
2015-05-02 | E-GEOD-65886 | biostudies-arrayexpress
GenomicsBromodomain protein BRD4 is required for estrogen receptor-dependent transcription and enhancer activation [ChIP-seq]
The estrogen receptor-α (ERα) is a transcription factor which plays a critical role in controlling cell proliferation and tumorigenesis by recruiting various cofactors to estrogen response elements (EREs) to induce or repress gene transcription. A deeper understanding of these transcriptional mechan...
ORGANISM(S): Homo sapiens 
2014-07-10 | E-GEOD-55921 | biostudies-arrayexpress
TranscriptomicsBromodomain protein BRD4 is required for estrogen receptor-dependent transcription and enhancer activation [RNA-Seq]
The estrogen receptor-M-NM-1 (ERM-NM-1) is a transcription factor which plays a critical role in controlling cell proliferation and tumorigenesis by recruiting various cofactors to estrogen response elements (EREs) to induce or repress gene transcription. A deeper understanding of these transcriptio...
ORGANISM(S): Homo sapiens 
2014-07-10 | E-GEOD-55922 | biostudies-arrayexpress
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