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TranscriptomicsGenome-Wide STAT5 binding sites in Kit225 leukemia cells
In order to systematically map STAT5 genomic binding sites and IL-2 mediated gene expression changes we mapped STAT5 binding sites using chip-on-ChIP in IL-2 dependent Kit225 cells that were either left un-stimulated or stimulated with IL-2 for 30 minutes. Using MAT analysis we identified 1581 STAT5...
ORGANISM(S): Homo sapiens 
2013-03-21 | E-GEOD-40619 | biostudies-arrayexpress
TranscriptomicsGenome-wide mapping of IL-2 regulated target genes and IL-2 activated STAT5 binding sites in Kit225 human leukemia cells.
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-03-21 | E-GEOD-40624 | biostudies-arrayexpress
TranscriptomicsIL-2 induced gene expression changes in Kit225 human leukemia cell lines
Identify IL-2 mediated genes in Kit225 cells. IL-2 withdrawn cells were treated with IL-2 or left untreated for 3 hours and then subjected to gene expression microarray analysis.
ORGANISM(S): Homo sapiens 
2013-03-21 | E-GEOD-40618 | biostudies-arrayexpress
TranscriptomicsPPARg and IL-4-induced gene expression data from PPARg +/- LysCre and PPARg fl/- LysCre mouse bone marrow-derived macrophages
Conditional macrophage-specific PPARg knockout mice were generated on C57Bl/6 background by breeding PPARg fl/- (one allele is floxed, the other is null) and lysozyme Cre transgenic mice. PPARg and IL-4 signaling was analyzed on bone marrow-derived macrophages. Bone marrow of 3 mice per group was is...
ORGANISM(S): Mus musculus 
2010-11-18 | E-GEOD-25123 | biostudies-arrayexpress
TranscriptomicsPPARg and IL-4-induced gene expression data from PPARg +/- LysCre and PPARg fl/- LysCre mouse bone marrow-derived alternatively activated macrophages and immature dendritic cells (iDCs)
Conditional macrophage-specific PPARg knockout mice were generated on C57Bl/6 background by breeding PPARg fl/- (one allele is floxed, the other is null) and lysozyme Cre transgenic mice. PPARg and IL-4 signaling was analyzed on bone marrow-derived macrophages. Bone marrow of 4 mice per group was is...
ORGANISM(S): Mus musculus 
2010-11-18 | E-GEOD-25125 | biostudies-arrayexpress
TranscriptomicsPPARg and IL-4-induced gene expression data from wild-type and STAT6 knockout mouse bone marrow-derived macrophages
C57Bl/6 wild-type and STAT6 KO mice were used to study PPARg and IL-4 signaling. Bone marrow of 3 mice per group was isolated and differentiated to macrophages with M-CSF (20 ng/ml). 20 ng/ml IL-4 was used to induce alternative macrophage activation and 1 uM Rosiglitazone (RSG) was used to activate ...
ORGANISM(S): Mus musculus 
2010-11-18 | E-GEOD-25088 | biostudies-arrayexpress
TranscriptomicsExpression data from human alternatively activated macrophages
Human CD14 positive monocytes were purified from healthy volunteers’ blood and cultured in vitro for 6 hours. While culturing, macrophages were activated alternatively with interleukin-4 (IL-4 100 ng/ml). Simultaneously, macrophages were also treated with vehicle (DMSO:ethanol) or 1uM synthetic PPAR...
ORGANISM(S): Homo sapiens 
2010-11-18 | E-GEOD-16386 | biostudies-arrayexpress
TranscriptomicsExpression data from human macrophages
Human CD14 positive monocytes were purified from healthy volunteers’ blood and cultured in vitro for 4, 12, 24, 72 hours. While culturing, macrophages were activated alternatively with interleukin-4 (IL-4 100 ng/ml) or classically with interferon-gamma (IFNg 100 ng/ml)+tumor necrosis factor (TNF 50 ...
ORGANISM(S): Homo sapiens 
2010-11-18 | E-GEOD-16385 | biostudies-arrayexpress
TranscriptomicsShort-term (12h) ATRA treatment of embryoid bodies.
We used microarrays to detail the global programme of gene expression in embryonic stem cells, early differentiated embrioid bodies and effect of short-term ATRA treatment. Expression data from undifferentiated mouse embryonic stem cells (D3), four-day old aggregated embrioid bodies and 12h atRA or ...
ORGANISM(S): Mus musculus 
2010-07-16 | E-GEOD-20919 | biostudies-arrayexpress
UnknownLessons on fruiting body morphogenesis from genomes and transcriptomes of Agaricomycetes.
Not available
S-EPMC10282164 | biostudies-literature
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