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TranscriptomicsDNA microarray studies of tumors grown in nude mice from breast cancer cells MDA-MB-231 overexpressing or not the angiotensin II AT2 receptor, and treated or not with AT2 agonist compound C21
This experiment aims at investigating the effect of AT2 overexpression and/or activation in breast cancer. Human breast cancer cells MDA-MB-231 were transfected with lentiviral construct containing flagged human AT2 receptor sequence (or empty vector) and were subcutaneously injected into immuno-def...
ORGANISM(S): Homo sapiens 
2020-11-07 | E-MTAB-8532 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression between borderline and adenocarcinoma in ovarian cancer
Ovarian tumors of the borderline subtype (BOL) are epithelial cancers tumors with very specific features. They rarely progress towards malignancy but their evolutionary profile, although remaining local, is distinct from that of benign cancers. At the cellular level, BOL are undistinguishable from m...
ORGANISM(S): Homo sapiens 
2022-12-31 | E-MTAB-11177 | biostudies-arrayexpress
TranscriptomicsIGR_BREAST_EXON_AGILENT_STUDY_FA
We profiled breast cancer samples with exon arrays (244K Agilent Human exon) in order to identify exons associated with higher risk of relapse. This set contain 178 single dual color of samples (biopsies) versus normal breast reference (Normal breast Clontech) , 5 dye-swap (10 hybridizations) and...
ORGANISM(S): Homo sapiens 
2013-05-07 | E-MTAB-1389 | biostudies-arrayexpress
TranscriptomicsThe metastatic microenvironment. Brain-derived soluble factors alter the malignancy phenotype of cutaneous and brain- metastasizing melanoma cells
The present study deals with functional interactions of cutaneous and brain-metastasizing human melanoma cells with brain-derived molecules. In this study we employed the unique melanoma xenograft model developed by Izraely and described in Int J Cancer. 2011 Oct 25. doi: 10.1002/ijc.27324. The pres...
ORGANISM(S): Homo sapiens 
2012-01-11 | E-GEOD-34970 | biostudies-arrayexpress
TranscriptomicsA Molecular Signature Associated with Human Melanoma Brain Metastasis and Spontaneous Micrometastasis
We established a model of human melanoma metastasis to identify differentially expressed genes in brain metastasis, compared to cutaneous melanoma from which they were developed. Such genes may control brain metastasis. The identification and characterization of these genes would advance the underst...
ORGANISM(S): Homo sapiens 
2011-03-17 | E-GEOD-27980 | biostudies-arrayexpress
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