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Our hypothesis is that dengue induces different innate immune responses in patients with mild respective severe dengue. We further hypothesize that severe dengue infection is a consequence of an over reactive inflammatory response which could be inhibited in an early stage by immune suppressants. We...
ORGANISM(S): Homo sapiens 
Dengue patient whole blood samples were analyzed during onset of disease, at defervescence and at early convalescence. Availability of samples at very early time points of disease allows to study the onset of the innate immune response. The main objective of the study is to understand early events d...
ORGANISM(S): Homo sapiens 
Febrile patients PCR positive for H1N1 swine flu, seasonal H1N1 and seasonal H3N2 in nasal swabs and controls consisting of febrile patients with rhinovirus infection or febrile patients of non-viral etiology (nasal swabs PCR negative for common respiratory viruses and blood PCR negative for dengu...
ORGANISM(S): Homo sapiens 
Whole blood from patients with acute dengue infection (as determined with PCR) were assessed for global transcriptional changes during different stages of the disease with reference to dengue virus IgG status at study inclusion Whole blood collected in PAX-gene tubes and extracted for total RNA
ORGANISM(S): Homo sapiens 
Cell lines B2B and 16HBE were infected in-vitro with rhinovirus 16 and comparisons were made to mock-infected cultures and cultures exposed to UV-irradiated rhinovirus. Total RNA were extracted and assessed by whole genome expression arrays. Rhinovirus in-vitro infected cell lines harvested at diffe...
ORGANISM(S): Homo sapiens 
Transcriptional profile in influenza infected patients with different clinical outcomes were investigated. Using gene expression profiling, we investigated the expression level of ~47,000 genes in the whole blood of patients with mild (83 patients), moderate (40 patients) and severe (11 patients) sy...
ORGANISM(S): Homo sapiens 
Transcriptional profile in Kawasaki patients at acute and convalescent phase with different clinical outcomes were investigated. To gain further insight into the molecular mechanisms underlying KD, we investigated the acute and convalescent whole blood transcriptional profiles of 171 KD subjects and...
ORGANISM(S): Homo sapiens 
Feature reduction of microarray data from mycobacteria treated with a variety of various clinical and investigational drugs We are using feature reduction to demonstrate that subsets of biomarker genes representative of the whole genome are sufficient for MOA classification and deconvolution in a me...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
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