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TranscriptomicsCross-species transcriptional network analysis defines shared inflammatory responses in murine and human lupus nephritis [Glomeruli]
Expression data from human with IgA nephropathy (IgAN) and hypertensive nephropathy (HT) We used microarrays to analyze the transcriptome of microdissected renal biopsies from patients with IgAN and HT RNA from glomeruli and tubulointerstitial compartments was extracted and processed for hybridizati...
ORGANISM(S): Homo sapiens 
2012-12-10 | E-GEOD-37460 | biostudies-arrayexpress
TranscriptomicsCross-species transcriptional network analysis defines shared inflammatory responses in murine and human lupus nephritis
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-12-10 | E-GEOD-37463 | biostudies-arrayexpress
TranscriptomicsCross-species transcriptional network analysis defines shared inflammatory responses in murine and human lupus nephritis[Tubulointerstitial]
Expression data from human with hypertensive nephropathy (HT) We used microarrays to analyze the transcriptome of microdissected renal biopsies from patients with HT RNA from glomeruli and tubulointerstitial compartments was extracted and processed for hybridization on Affymetrix microarrays.
ORGANISM(S): Homo sapiens 
2012-12-10 | E-GEOD-37455 | biostudies-arrayexpress
TranscriptomicsExpression data from lupus NZB/W, NZM2410, NZW/BXSB mouse kidneys prenephritic and nephritic.
Nephritis (LN) is a serious manifestation of SLE. Therapeutic studies in mouse LN models do not always predict outcomes of human therapeutic trials, raising concerns about the human relevance of these models. In this study we used an unbiased transcriptional network approach to define similarities a...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-32583 | biostudies-arrayexpress
ProteomicsSirtuin 5 Reduces Malonylation in Non-mitochondrial Metabolic Pathways in Diabetic Kidney Disease
Early diabetic kidney disease (DKD) is marked by dramatic metabolic reprogramming due to nutrient excess, mitochondrial dysfunction, and increased renal energy requirements from hyperfiltration. We hypothesized that changes in metabolism in DKD may be regulated by Sirtuin 5 (SIRT5), a deacylase that...
ORGANISM(S): Mus Musculus 
2023-06-26 | PXD037819 | panorama
TranscriptomicsCyclodextrin protects podocytes in diabetic kidney disease [HumanWG-6 v3.0 array]
Analysis of gene expression changes in differentiated human podocytes treated with the serum from patients with (DKD+) or without (DKD-) diabetic kidney disease when compared to normal subjects (C). The hypothesis is that the three groups can be distinghed by their differential gene expression patte...
ORGANISM(S): Homo sapiens 
2013-07-11 | E-GEOD-46897 | biostudies-arrayexpress
TranscriptomicsCyclodextrin protects podocytes in diabetic kidney disease [HumanHT-12 V4.0 array]
Analysis of gene expression changes in differentiated human podocytes treated with the serum from patients with (DKD+) or without (DKD-) diabetic kidney disease when compared to normal subjects (C). The hypothesis is that the three groups can be distinghed by their differential gene expression patte...
ORGANISM(S): Homo sapiens 
2013-07-13 | E-GEOD-46899 | biostudies-arrayexpress
TranscriptomicsCyclodextrin protects podocytes in diabetic kidney disease.
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-07-11 | E-GEOD-46900 | biostudies-arrayexpress
TranscriptomicsTissue Transcriptome Driven Identification of Epidermal Growth Factor as a Chronic Kidney Disease Biomarker
We identified EGF as the top candidates predicting kidney function through an intrarenal transcriptome-driven approach, and demonstrated it is an independent risk predictor of CKD progression and can significantly improve prediction of renal outcome by established clinical parameters in diverse popu...
ORGANISM(S): Homo sapiens 
2015-12-14 | E-GEOD-69438 | biostudies-arrayexpress
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