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ModelsHayashi1999_NOSynth_Phospho
This model features the phosphorylation of rat brain neuronal NOS expressed in E. coli or Sf9 cells, which leads to a decrease in Vmax of the phosphorylated enzyme, with little change of both the Km for L-arginine and Kact for CaM. This is based on Hayashi Y. et al. J Biol Chem. (1999) 274(29):20597...
2005-01-01 | MODEL4780784080 | BioModels
TranscriptomicsModelling and rescuing neurodevelopmental defect of Down syndrome using induced pluripotent stem cells from monozygotic twins discordant for trisomy 21 [RNA-seq]
Down syndrome (trisomy 21) is the most common viable chromosomal disorder with intellectual impairment and several other developmental abnormalities. Here, we report the generation and characterization of induced pluripotent stem cells (iPSCs) derived from monozygotic twins discordant for trisomy 21...
ORGANISM(S): Homo sapiens 
2013-12-01 | E-GEOD-52249 | biostudies-arrayexpress
UnknownStaphylococcus aureus Isolated from Skin from Atopic-Dermatitis Patients Produces Staphylococcal Enterotoxin Y, Which Predominantly Induces T-Cell Receptor Vα-Specific Expansion of T Cells.
Not available
S-EPMC6977126 | biostudies-literature
UnknownOptimal design and validation of antiviral siRNA for targeting HIV-1.
Not available
S-EPMC2204037 | biostudies-literature
UnknownS-adenosyl-L-methionine is an effector in the posttranscriptional autoregulation of the cystathionine gamma-synthase gene in Arabidopsis.
Not available
S-EPMC193543 | biostudies-literature
TranscriptomicsComparison of gene expression in NOD versus NOD.NOR-Chr4 (NR4) splenic B cells.
Type 1 Diabetes (T1D) in humans and the non-obese diabetic (NOD) mouse model results from autoreactive T cell destruction of pancreatic beta cells. A pathogenic role for B lymphocytes (B cells) in T1D first became evident when NOD mice made deficient in this population through introduction of an ina...
ORGANISM(S): Mus musculus 
2012-06-07 | E-GEOD-37294 | biostudies-arrayexpress
TranscriptomicsOver expression of mRNA for multiple genes including insulin in the PLN of NOD is associated with Islet Autoimmunity
The aim of this study is to identify genes implicated in the early steps of the autoimmune process, prior to inflammation in type 1 diabetes. Early Insulin AutoAntibodies (E-IAA) have been used as subphenotypic marker to select individual animals as type 1 diabetes prone and to compare gene expressi...
ORGANISM(S): Mus musculus 
2009-10-02 | E-GEOD-15582 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiles of tumor sorted fractions demarcating genetic instability using DNA-RNA content based cell cycle analysis in ovarian cancer xenograft tumor
Our earlier report states role of genetic instability and aneuploid cells in drug resistance and tumor recurrence. Hence segregating tumor based on DNA content is a good model to study genetic in stability. We have earlier reported isolation of cell line (A4T) from a patient with Grade IV serous ad...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-74852 | biostudies-arrayexpress
UnknownPhotoreaction pathways and photointermediates of retinal-binding photoreceptor proteins as revealed by in situ photoirradiation solid-state NMR spectroscopy.
Not available
S-EPMC6441423 | biostudies-literature
UnknownDecreased number of inpatients with community-acquired pneumonia during the COVID-19 pandemic: A large multicenter study in Japan.
Not available
S-EPMC8776425 | biostudies-literature
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