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TranscriptomicsChIP profiling by array of histone modifications in normal human islets
This experiment used ChIP-seq technology to create a genome-wide profile of histone marks in normal human pancreatic islets. In the current work we analyzed two histone marks associated with gene expression (H3K4me3, H3K4me1) and marks associated with gene repression(H3K27me3). Each mark was anayze...
ORGANISM(S): Homo sapiens 
2010-02-18 | E-MTAB-191 | biostudies-arrayexpress
GenomicsChIP-Seq of human normal pancreatic islets with anti-histone antibodies to analyse histone modifications
This experiment used ChIP-seq technology to create a genome-wide profile of histone marks in normal human pancreatic islets. In the current work we analyzed two histone marks associated with gene expression (H3K4me3, H3K4me1) and marks associated with gene repression(H3K27me3). Each mark was anayze...
ORGANISM(S): Homo sapiens 
2010-02-18 | E-MTAB-189 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-seq of human pancreatic endocrine cells from Juvenile, adult control and type 2 diabetic donors.
We successfully sequenced and annotated more than 400 cells from child, adult control, type 1 diabetes and type 2 diabetes donors. We detect donor-type specific transcript variation. We also report that cells from child donors have less defined gene signature. Cells from type 2 diabetes donors resem...
ORGANISM(S): Homo sapiens 
2016-07-05 | E-GEOD-83139 | biostudies-arrayexpress
TranscriptomicsEpigenetic regulation of the MEG3-DLK1 microRNA cluster in human Type 2 diabetic islets
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the insulin-producing β-cells in the endocrine pancreas to overcome insulin resistance in peripheral tissues. To determine if microRNAs are involved in the pathogenesis of human T2DM, we sequenced the small RNAs o...
ORGANISM(S): Homo sapiens 
2013-11-22 | E-GEOD-51924 | biostudies-arrayexpress
TranscriptomicsIntegration of ATAC-seq and RNA-seq Identifies Human Alpha Cell and Beta Cell Signature Genes
Objective: Although glucagon-secreting α-cells and insulin-secreting β-cells have opposing functions in regulating plasma glucose levels, the two cell types share a common developmental origin and have overlaps in their transcriptome and epigenome profiles. Notably, destruction of one of these cel...
ORGANISM(S): Homo sapiens 
2015-12-23 | E-GEOD-76268 | biostudies-arrayexpress
UnknownPredicting California bearing ratio of HARHA-treated expansive soils using Gaussian process regression.
Not available
S-EPMC10442396 | biostudies-literature
UnknownManaging obesity in children: a clinical practice guideline.
Not available
S-EPMC12007946 | biostudies-literature
TranscriptomicsEpigenomic plasticity enables human pancreatic alpha to beta cell reprogramming
Insulin-secreting β cells and glucagon-secreting α cells maintain physiological blood glucose levels, and their malfunction drives diabetes development. Using ChIP sequencing and RNA sequencing analysis, we determined the epigenetic and transcriptional landscape of human pancreatic α, β, and exocrin...
ORGANISM(S): Homo sapiens 
2013-08-28 | E-GEOD-50386 | biostudies-arrayexpress
GenomicsThe Pdx1 Cistrome of Pancreatic Islets
We performed global location analysis of Pdx1 occupancy in mouse and human islets.
ORGANISM(S): Mus musculus 
2012-05-23 | E-MTAB-1143 | biostudies-arrayexpress
TranscriptomicsEpigenetic regulation of the MEG3-DLK1 microRNA cluster in human Type 2 diabetic islets
Type 2 diabetes mellitus (T2DM) is a multi-factorial disease characterized by the inability of beta-cells in the endocrine pancreas to produce sufficient amounts of insulin to overcome insulin resistance in peripheral tissue. To investigate the function of miRNAs in T2DM, we sequenced the small RNAs...
ORGANISM(S): Homo sapiens 
2013-12-01 | E-GEOD-52314 | biostudies-arrayexpress
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