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TranscriptomicsGenome-wide localization of ORC and MCM binding sites and identification of replication origins in S. pombe
DNA replication of eukaryotic chromosomes initiates at a number of discrete loci, called replication origins. Distribution and regulation of origins are important for complete duplication of the genome. Here, we determined locations of Orc1 and Mcm6, components of pre-replicative complex (pre-RC),...
ORGANISM(S): Schizosaccharomyces pombe 
2010-06-11 | E-GEOD-6523 | biostudies-arrayexpress
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Cell NAMPTi treatment)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7251 | MetaboLights
UnknownVitamin D Regulates Maternal T-Helper Cytokine Production in Infertile Women.
Not available
S-EPMC6073370 | biostudies-literature
ProteomicsProteomic analyses of iron deprived NK92 cells with deferoxamine or PPMX-T003
This work aims to detect the differentially expressed proteins between transferrin receptor 1 inhibition and iron chelation in a natural killer cell lymphoma-derived cell line NK92. Cells were treated with 500 μM deferoxamine or 10 μg/mL PPMX-T003 (an anti-transferrin receptor 1 inhibitory antibody)...
ORGANISM(S): Homo Sapiens (human) 
2025-07-04 | PXD059223 | JPOST Repository
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