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TranscriptomicsExpression data from Evi1-transduced primary bone marrow cells
Evi1 is essential for proliferation of hematopoietic stem cells and implicated in the development of myeloid disorders. Particularly, high Evi1 expression defines one of the largest clusters in acute myeloid leukemia and is significantly associated with extremely poor prognosis. Improvement of the t...
ORGANISM(S): Mus musculus 
2010-07-08 | E-GEOD-22434 | biostudies-arrayexpress
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Cell NAMPTi treatment)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7251 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAD targeted time-course)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7253 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAMPT targeted therapy)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7252 | MetaboLights
UnknownPositive feedback between NF-κB and TNF-α promotes leukemia-initiating cell capacity.
Not available
S-EPMC3904603 | biostudies-literature
UnknownHomemade blenderized tube feeding improves gut microbiome communities in children with enteral nutrition.
Not available
S-EPMC10482415 | biostudies-literature
TranscriptomicsTranscription profiling of mouse double negative thymocytes
In order to understand the molecular mechanisms of DN thymocyte development, it may be also of use to clarify how these developmental processes are regulated in terms of their entire gene expression, to which cell differentiation is ultimately ascribed. In the current study, we approached this iss...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7784 | biostudies-arrayexpress
UnknownFree-flap volume correlates with body mass index in patients with tongue squamous cell carcinoma.
Not available
S-EPMC10601574 | biostudies-literature
UnknownDifferential Discontinuation Profiles between Pirfenidone and Nintedanib in Patients with Idiopathic Pulmonary Fibrosis.
Not available
S-EPMC8750555 | biostudies-literature
UnknownEvi1 defines leukemia-initiating capacity and tyrosine kinase inhibitor resistance in chronic myeloid leukemia.
Not available
S-EPMC4217142 | biostudies-literature
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