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UnknownHeterozygous Dab1 Null Mutation Disrupts Neocortical and Hippocampal Development.
Loss-of-function mutations in Reelin and DAB1 signaling pathways disrupt proper neuronal positioning in the cerebral neocortex and hippocampus, but the underlying molecular mechanisms remain elusive. Here, we report that heterozygous yotari mice harboring a single autosomal recessive yotar...
S-EPMC10089055 | biostudies-literature
UnknownA Unique "Reversed" Migration of Neurons in the Developing Claustrum.
The claustrum (CLA) is a cluster of neurons located between the insular cortex and striatum. Many studies have shown that the CLA plays an important role in higher brain function. Additionally, growing evidence suggests that CLA dysfunction is associated with neuropsychological symptoms. However, ho...
S-EPMC9899091 | biostudies-literature
UnknownMaternal immunoglobulins are distributed in the offspring's brain to support the maintenance of cortical interneurons in the postnatal period.
It is known that maternal immunoglobulins (Igs) are transferred to the offspring across the placenta. However, receiving maternal Igs, especially before the blood-brain barrier (BBB) is formed in the offspring's brain, carries the risk of transferring some brain-reactive Igs. It is thus hypothesized...
S-EPMC11094934 | biostudies-literature
UnknownDrebrin-like (Dbnl) Controls Neuronal Migration via Regulating N-Cadherin Expression in the Developing Cerebral Cortex.
The actin cytoskeleton is crucial for neuronal migration in the mammalian developing cerebral cortex. The adaptor protein Drebrin-like (Dbnl) plays important roles in reorganization of the actin cytoskeleton, dendrite formation, and endocytosis by interacting with F-actin, cobl, and dynamin. Althoug...
S-EPMC6343645 | biostudies-literature
UnknownReelin transiently promotes N-cadherin-dependent neuronal adhesion during mouse cortical development.
Reelin is an essential glycoprotein for the establishment of the highly organized six-layered structure of neurons of the mammalian neocortex. Although the role of Reelin in the control of neuronal migration has been extensively studied at the molecular level, the mechanisms underlying Reelin-depend...
S-EPMC5338414 | biostudies-literature
UnknownErratic and blood vessel-guided migration of astrocyte progenitors in the cerebral cortex.
Astrocytes are one of the most abundant cell types in the mammalian brain. They play essential roles in synapse formation, maturation, and elimination. However, how astrocytes migrate into the gray matter to accomplish these processes is poorly understood. Here, we show that, by combinational analys...
S-EPMC9630450 | biostudies-literature
UnknownNational trends in the outcomes of subarachnoid haemorrhage and the prognostic influence of stroke centre capability in Japan: retrospective cohort study.

Objectives

To examine the national, 6-year trends in in-hospital clinical outcomes of patients with subarachnoid haemorrhage (SAH) who underwent clipping or coiling and the prognostic influence of temporal trends in the Comprehensive Stroke Center (CSC) capabilities on patient outcomes in Ja...
S-EPMC10111904 | biostudies-literature
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