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ProteomicsIdentification of acetylated proteins in the hearts of mice fed a ketogenic diet
Diets influence metabolism and susceptibility to disease. We have previously demonstrated that a ketogenic diet alleviates cardiac pathology, with its cardioprotective effects linked to increased lysine acetylation in the heart. To identify acetylated proteins associated with this diet, we conducted...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-03 | PXD059855 | Pride
Heart Acetylation Ketogenic diet Hypertension 
ProteomicsInteraction proteins with KAT6A
Lysine acetyltransferases (KATs) catalyze the transfer of acetyl groups from acetyl-CoA to lysine residues. Our proteomic analysis revealed that KAT6A is acetylated at lysine 815 (K815), corresponding to mouse K816, in the hearts of mice fed a ketogenic diet under high blood pressure. To identify ch...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-11-03 | PXD059838 | Pride
Lysine acetyltransferase Kat6a Cardiomyocyte 
ProteomicsPhosphorylation of Bcl-xL by ERK1
The anti-apoptotic function of Bcl-xL in the heart against reperfusion injury is diminished by K-Ras-Mst1-mediated phosphorylation of Ser14, which allows dissociation of Bcl-xL from Bax and promotes cardiomyocyte death. Here we show that Ser14 phosphorylation of Bcl-xL is also promoted by hemodynami...
ORGANISM(S): Homo sapiens (Human) 
2023-09-06 | PXD045118 | Pride
Human Phosphorylation Mitogen-activated protein kinase 3 Bcl-2-like protein 1 
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