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TranscriptomicsValidation of EZH2 targets in GSCs treated with shNT (control), shMELK, shFOXM1, and EZH2 overexpression
We demonstrate that the catalytic subunit of Polycomb Repressive Complex 2, EZH2, is targeted by the MELK-FOXM1 complex, which in turn promotes resistance to radiation in GSCs. Clinically, EZH2 and MELK are co-expressed in GBM and significantly induced in post-irradiation recurrent tumors whose expr...
ORGANISM(S): Homo sapiens 
2015-04-16 | E-GEOD-63963 | biostudies-arrayexpress
TranscriptomicsEffect on fatty acid oxidation by etomoxir and etomoxir plus beta-hydroxybutyrate in Glioma-derived Mesenchymal stem cells
The experiment was carried out in triplicates in untreated, etomoxir treated and etomoxir plus beta-hydroxybutyrate (3HB) treated conditions. MES83 (Glioma-derived Mesenchymal stem cells) were either untreated or treated with 40uM of etomoxir alone or in combination with 0.5mM of beta-hydroxybutyrat...
ORGANISM(S): Homo sapiens 
2020-03-31 | E-MTAB-8017 | biostudies-arrayexpress
UnknownVirus Sensor RIG-I Represses RNA Interference by Interacting with TRBP through LGP2 in Mammalian Cells.
Not available
S-EPMC6210652 | biostudies-literature
UnknownNear-infrared <i>in vivo</i> imaging system for dynamic visualization of lung-colonizing bacteria in mouse pneumonia.
Not available
S-EPMC11537041 | biostudies-literature
UnknownHepatectomy leads to loss of TRAIL-expressing liver NK cells via downregulation of the CXCL9-CXCR3 axis in mice.
Not available
S-EPMC5663402 | biostudies-literature
UnknownLGP2 virus sensor enhances apoptosis by upregulating apoptosis regulatory genes through TRBP-bound miRNAs during viral infection.
Not available
S-EPMC7026649 | biostudies-literature
TranscriptomicsGlioma stem cell treatment with MELK-signaling inhibitors
Glioblastoma multiforme (GBM) is a highly lethal brain tumor. Due to resistance to current therapies, patient prognosis remains poor and development of novel and effective GBM therapy is crucial. Glioma stem cells (GSCs) have gained attention as therapeutic target in GBM due to their relative resist...
ORGANISM(S): Homo sapiens 
2013-08-28 | E-GEOD-50227 | biostudies-arrayexpress
UnknownExperimental Adaptive Evolution of Simian Immunodeficiency Virus SIVcpz to Pandemic Human Immunodeficiency Virus Type 1 by Using a Humanized Mouse Model.
Not available
S-EPMC5790958 | biostudies-literature
TranscriptomicsA Proneural to Mesenchymal Transition Mediated by NFkB Promotes Radiation Resistance in Glioblastoma (part 2)
SUMMARY Despite numerous genome-wide association studies involving glioblastoma (GBM), few therapeutic targets have been identified for this disease. Using patient derived glioma sphere cultures (GSCs), we have found that a subset of the proneural (PN) GSCs undergo transition to a mesenchymal (MES)...
ORGANISM(S): Homo sapiens 
2013-08-15 | E-GEOD-49162 | biostudies-arrayexpress
TranscriptomicsA Proneural to Mesenchymal Transition Mediated by NFkB Promotes Radiation Resistance in Glioblastoma (part 1)
SUMMARY Despite numerous genome-wide association studies involving glioblastoma (GBM), few therapeutic targets have been identified for this disease. Using patient derived glioma sphere cultures (GSCs), we have found that a subset of the proneural (PN) GSCs undergo transition to a mesenchymal (MES)...
ORGANISM(S): Homo sapiens 
2013-08-15 | E-GEOD-49161 | biostudies-arrayexpress
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